ZM323881
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- CAS号:
- 193001-14-8
- 英文名:
- 5-((7-(BENZYLOXY)QUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHENOL
- 英文别名:
- CS-744;ZM323881;KDR/FLK-1 INHIBITOR V;VEGF RECEPTOR 2 KINASE INHIBITOR V;5-((7-(BENZYLOXY)QUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHENOL;4-Fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]phenol;Phenol, 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-
- 中文名:
- ZM323881
- 中文别名:
- 化合物 T21540;4-氟-2-甲基-5-[[7-(苯基甲氧基)-4-喹唑啉基]氨基]苯酚
- CBNumber:
- CB6811963
- 分子式:
- C22H18FN3O2
- 分子量:
- 375.4
- MOL File:
- Mol file
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ZM323881化学性质
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沸点:
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543.6±50.0 °C(Predicted)
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密度:
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1.342±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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White to off-white solid.
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酸度系数(pKa):
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9.99±0.23(Predicted)
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ZM323881性质、用途与生产工艺
ZM323881是有效,选择性的 VEGFR2 抑制剂, IC50 值小于2 nM。
ZM323881 is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity anddemonstrates excellent selectivity versus other receptor tyrosine kinases, including PDGFRβ, FGFR1, EGFR and erbB2 (IC
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>50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation(IC
50
=8 nM) and VEGFR2 tyrosine phosphorylation. ZM323881 inhibits activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor. In HAECs, ZM323881 completely inhibits VEGF-induced ERK phosphorylation at 1 μM.
ZM323881
上下游产品信息
上游原料
下游产品
193001-14-8, ZM323881 相关搜索:
- 化合物 T21540
- 4-氟-2-甲基-5-[[7-(苯基甲氧基)-4-喹唑啉基]氨基]苯酚
- 193001-14-8
- Phenol, 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-
- CS-744
- 4-Fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]phenol
- ZM323881
- VEGF RECEPTOR 2 KINASE INHIBITOR V
- KDR/FLK-1 INHIBITOR V
- 5-((7-(BENZYLOXY)QUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHENOL