盐酸哌罗克生
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- CAS号:
- 135-87-5
- 英文名:
- 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]piperidinium chloride
- 英文别名:
- 933F;piperoxan.HC;piperoxan.HCl;933F Hydrochloride;Benodaine hydrochloride;Piperoxane hydrochloride;Piperoxan (hydrochloride);Benzodioxane hydrochloride;2-Piperidinomethyl-1,4-benzodioxan hydrochloride;Piperoxan hydrochloride (Benodaine hydrochloride)
- 中文名:
- 盐酸哌罗克生
- 中文别名:
- 盐酸吡哌咯生;盐酸哌罗克生
- CBNumber:
- CB6883731
- 分子式:
- C14H20ClNO2
- 分子量:
- 269.7671
- MOL File:
- 135-87-5.mol
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盐酸哌罗克生化学性质
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熔点:
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229-231 °C
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储存条件:
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Store at -20°C
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溶解度:
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Chloroform: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
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形态:
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Solid
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盐酸哌罗克生性质、用途与生产工艺
Piperoxan hydrochloride (Benodaine, Fourneau 933, F933, DL-Piperoxan) 是 α2 (alpha 2) adrenoceptor 的拮抗剂。
| Target | Value |
α2 adrenoceptor
()
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When the medulla is superfused with α
2
adrenoceptor antagonist Piperoxane (50 μM; 5 min) while the pons is with artificial cerebrospinal fluid (ACSF), the three inactive preparations display rhythmic phrenic bursts at a low frequency (2-4 c/min), and the phrenic burst frequency of the 12 active ones significantly increases during the last 3 min of Piperoxane applications (163±12% of the previous mean frequency). In active medullary preparations, the effects of NA applications (25 μM; 5 min) are compared when the preparations sre superfused either by ACSF (n=8) or by the α2 adrenoceptor antagonist Piperoxane (50 μM; PIP-ACSF; n=5). NA applications either alone (NA-ACSF) or with Piperoxane (PIP-ACSF+NA) significantly increases the phrenic burst frequency. However, the blockage of the medullary α2 adrenoceptors by Piperoxane potentiates a phrenic burst frequency increase: during the fifth minute of NA applications, the phrenic burst frequency reached 171±11% of the mean control value when ACSF is applied alone and 234±21% of the mean control value when PIP-ACSF is applied in control condition.
类别
有毒物品
毒性分级
中毒
急性毒性
口服-小鼠 LD50; 502 毫克/公斤; 腹腔-小鼠 LD50: 175 毫克/公斤
可燃性危险特性
可燃; 燃烧产生有毒氮氧化物和氯化氢烟雾
储运特性
通风低温干燥
灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水
盐酸哌罗克生
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100850 | 盐酸哌罗克生
Piperoxan hydrochloride | 135-87-5 | 5mg | 1200元 |
| 2024/04/30 | HY-100850 | 盐酸哌罗克生
Piperoxan hydrochloride | 135-87-5 | 10mM * 1mLin DMSO | 1320元 |
135-87-5, 盐酸哌罗克生 相关搜索:
- 药靶配体
- 盐酸吡哌咯生
- 盐酸哌罗克生
- 135-87-5
- Piperoxan hydrochloride,Piperoxan,Beta Receptor,Adrenergic Receptor,inhibit,Inhibitor,Benodaine
- Piperoxan hydrochloride (Benodaine hydrochloride)
- piperoxan.HC
- Piperoxane hydrochloride
- piperoxan.HCl
- Piperoxan (hydrochloride)
- Benzodioxane hydrochloride
- Benodaine hydrochloride
- 933F Hydrochloride
- 933F
- 2-Piperidinomethyl-1,4-benzodioxan hydrochloride
- 2-(1-Piperidylmethyl)-1,4-benzodioxan hydrochloride
- 1,4-Benzodioxan, 2-(1-piperidylmethyl)-, hydrochloride
- 1-(1,4-Benzodioxan-2-ylmethyl)piperidine hydrochloride
- 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]piperidinium chloride