NETAMIFTIDE
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- CAS号:
- 204992-09-6
- 英文名:
- NETAMIFTIDE
- 英文别名:
- NETAMIFTIDE;Nemifitide di;INN 00835 diTFA;Nemifitide diTFA;Bis(trifluoroacetate);Nemifitide Ditriflutate;Netamiftide ditriflutate;H-Phe（4-F）-Hyp-Arg-Gly-Trp-NH2;(2S)-N-[(1S)-1-[[(1S)-1-[[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoylmethylcarbamoyl]-4-(diaminomethylideneamino)butyl]-4-hydroxy-pyrrolidine-2-carboxamide
- 中文名:
- NETAMIFTIDE
- 中文别名:
- 五肽INN 00835;NEMIFITIDE DITFA;FLUORO-PHE-HYP-ARG-GLY-TRP-NH2
- CBNumber:
- CB71011493
- 分子式:
- C35H44F4N10O8
- 分子量:
- 808.79
- MOL File:
- 204992-09-6.mol
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NETAMIFTIDE化学性质
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储存条件:
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Store at -20°C
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水溶解性:
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Water: 250 mg/mL (270.91 mM)
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NETAMIFTIDE性质、用途与生产工艺
Nemifitide diTFA (INN 00835 diTFA) 是一种合成的五肽抗抑郁药，具有迅速起效的潜力。Nemifitide diTFA 是黑色素细胞抑制因子 (MIF) 的肽类似物。Nemifitide diTFA 可以透过血脑屏障。
Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT
2A
, 5-HT
2C
, melanocortin MC4, MC5 and bombesin.
Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect.
Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses.
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Animal Model:
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Male Flinders Sensitive Line (FSL) rat weighing 280-320 g
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Dosage:
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0.3 mg/kg
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Administration:
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IP; daily; for 14 days
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Result:
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Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect.
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NETAMIFTIDE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-105077A | NETAMIFTIDE
Nemifitide diTFA | 204992-09-6 | 5mg | 2500元 |
| 2024/04/30 | HY-105077A | NETAMIFTIDE
Nemifitide diTFA | 204992-09-6 | 10mg | 4500元 |
204992-09-6, NETAMIFTIDE 相关搜索:
- 目录肽
- 多肽
- C37H45F7N10O10
- 五肽INN 00835
- FLUORO-PHE-HYP-ARG-GLY-TRP-NH2
- NEMIFITIDE DITFA
- 204992-09-6
- H-Phe（4-F）-Hyp-Arg-Gly-Trp-NH2
- Nemifitide Ditriflutate
- Nemifitide di
- INN 00835 diTFA
- Nemifitide diTFA
- Netamiftide ditriflutate
- (2S)-N-[(1S)-1-[[(1S)-1-[[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoylmethylcarbamoyl]-4-(diaminomethylideneamino)butyl]-4-hydroxy-pyrrolidine-2-carboxamide
- NETAMIFTIDE
- Bis(trifluoroacetate)