黄羽扇豆魏特酮
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- CAS号:
- 104691-86-3
- 英文名:
- 8-PRENYLGENISTEIN
- 英文别名:
- Lupiwighteone;Luncheonette;8-PRENYLGENISTEIN;8-Isopentenylgenistein;4',5,7-Trihydroxy-8-prenylisoflavone;4',5,7-Trihydroxy-8-isopentenylisoflavone;5,7-Dihydroxy-3-(4-hydroxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one;3-(4-Hydroxyphenyl)-5,7-dihydroxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;5,7-Dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one,5,7-dihydroxy-3- (4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-
- 中文名:
- 黄羽扇豆魏特酮
- 中文别名:
- 黄羽扇豆魏特酮;5,7-二羟基-3-(4-羟基苯基)-8-(3-甲基-2-丁烯-1-基)-4H-苯并吡喃-4-酮
- CBNumber:
- CB7246036
- 分子式:
- C20H18O5
- 分子量:
- 338.35
- MOL File:
- Mol file
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黄羽扇豆魏特酮化学性质
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熔点:
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133-135℃
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沸点:
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583.5±50.0 °C(Predicted)
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密度:
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1.351±0.06 g/cm3(Predicted)
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储存条件:
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4°C, protect from light
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溶解度:
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DMSO : 100 mg/mL (295.55 mM; Need ultrasonic)
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形态:
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Powder
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酸度系数(pKa):
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6.62±0.20(Predicted)
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黄羽扇豆魏特酮性质、用途与生产工艺
Lupiwighteone 是一种广泛存在于野生植物中的异黄酮，具有抗氧化、抗菌和抗癌作用。Lupiwighteone 通过抑制 PI3K/Akt/mTOR 通路，诱导人乳腺癌细胞 caspase 依赖性和非依赖性凋亡 (apoptosis)。
Lupiwighteone (2-100 μM; 72 hours) shows cytotoxicity towards various cell lines, especially on DU-145 cells and SGC-7901 cells with IC
50
s of 23.7 μM and 21 μM, respectively.
Lupiwighteone (20-60 μM; 48 hours) induces (cell cycle arrest in DU-145 cells.
Lupiwighteone (20-60 μM; 48 hours) induces cells apoptosis.
Lupiwighteone (20-60 μM; 48 hours) decreases the cell cycle-related protein expressions in a dose-dependent manner in DU-145 cells.
Lupiwighteone (20-60 μM; 48 hours) induces a dose-dependent increase in ROS production.
Lupiwighteone up-regulates of cytochrome c and caspase-3, and subsequent cleavage of PARP-1 and down-regulates of the p-Akt/Akt ratio and VEGF expression, suggests the activation of mitochondria-based intrinsic apoptosis in DU-145 cells.
Cell Viability Assay
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Cell Line:
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DU-145 cells, C4-2 cells, SGC-7901 cells, Hela cells, HUVEC, MCF-7 cells, CNE cells, Vero
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Concentration:
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2 μM, 5 μM, 25 μM, 50 μM, 100 μM
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Incubation Time:
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72 hours
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Result:
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Had inhibition on the survival of many cancer cell lines and HUVEC.
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Cell Cycle Analysis
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Cell Line:
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DU-145 cells
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Concentration:
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20 μM, 40 μM, 60 μM
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Incubation Time:
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48 hours
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Result:
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Induced cell cycle arrest.
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Apoptosis Analysis
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Cell Line:
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DU-145 cells
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Concentration:
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20 μM, 40 μM, 60 μM
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Incubation Time:
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48 hours
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Result:
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Induced apoptosis.
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Western Blot Analysis
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Cell Line:
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DU-145 cells
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Concentration:
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20 μM, 40 μM, 60 μM
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Incubation Time:
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48 hours
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Result:
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Decreased CDK1, 2, 4, 6, cyclinD1, and cyclinB1 protein expression in a dose-dependent manner.
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黄羽扇豆魏特酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-N3354 | Lupiwighteone | | 5 mg | 4100元 |
| 2024/04/30 | HY-N3354 | Lupiwighteone | | 10 mg | 7300元 |
104691-86-3, 黄羽扇豆魏特酮 相关搜索:
- Miscellaneous Natural Products
- 标准品
- 黄酮
- 5,7-二羟基-3-(4-羟基苯基)-8-(3-甲基-2-丁烯-1-基)-4H-苯并吡喃-4-酮
- 黄羽扇豆魏特酮
- 104691-86-3
- 5,7-Dihydroxy-3-(4-hydroxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
- PI3K,Apoptosis,antioxidant,Inhibitor,isoflavone,mTOR,antimicrobial,Akt,inhibit,Lupiwighteone,8-prenylgenistein
- Lupiwighteone
- 4H-1-Benzopyran-4-one,5,7-dihydroxy-3- (4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-
- Luncheonette
- 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-
- 8-Isopentenylgenistein
- 4',5,7-Trihydroxy-8-prenylisoflavone
- 4',5,7-Trihydroxy-8-isopentenylisoflavone
- 3-(4-Hydroxyphenyl)-5,7-dihydroxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
- 5,7-Dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
- 8-PRENYLGENISTEIN