BVT 2733
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- CAS号:
- 376640-41-4
- 英文名:
- BVT 2733
- 英文别名:
- BVT2733, >98%;BVT 2733(BVT.2733);BVT.2733 >=98% (HPLC);3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide;BENZENESULFONAMIDE, 3-CHLORO-2-METHYL-N-[4-[2-(4-METHYL-1-PIPERAZINYL)-2-OXOETHYL]-2-THIAZOLYL]-;3-CHLORO-2-METHYL-N-[4-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHYL]-1,3-THIAZOL-2-YL]BENZENESULFONAMIDE;HFD,CIA,BVT-2733,J774.1,arthritis,macrophage,collagen,inhibit,BVT2733,BVT 2733,disease,adipocyte,Inhibitor,obesity
- 中文名:
- BVT 2733
- 中文别名:
- 化合物BVT 2733;3-氯-2-甲基-N-(4-(2-(4-甲基哌嗪-1-基)-2-氧代乙基)噻唑-2-基)苯磺酰胺
- CBNumber:
- CB72667358
- 分子式:
- C17H21ClN4O3S2
- 分子量:
- 428.96
- MOL File:
- 376640-41-4.mol
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BVT 2733化学性质
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沸点:
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636.9±65.0 °C(Predicted)
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密度:
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1.427±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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≥42.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
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形态:
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solid
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酸度系数(pKa):
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6.36±0.10(Predicted)
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BVT 2733性质、用途与生产工艺
BVT 2733 是一种新型的、小分子、非甾体类、异构体选择性的 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) 的抑制剂。
BVT 2733 (100 μM; 24 hours) co-treatment with PA (100 µM) reduces MCP-1 expression in fully differentiation adipocytes.BVT 2733 (50-100 μM; 24 hours) reduces the inflammation protein levels (MCP-1, IL-6) in medium in J774.1 macrophages by Elisa.
RT-PCR
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Cell Line:
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Differentiation adipocytes
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Concentration:
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100 μM
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Incubation Time:
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24 hours
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Result:
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Down-regulated MCP-1 mRNA level.
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BVT-2733 (oral administration; 100 mg/kg; twice daily; 2 weeks) attenuates the arthritis severity and anti-CII level and decreases the levels of serum TNF-α, IL-1β, IL-6 and IL-17 in CIA mice.BVT 2733 (oral administration; 100 mg/kg; dosed (09.00 and 17.00 h); last 4 weeks) exhibits decreased body weight and enhanced glucose tolerance and insulin sensitivity when it compares to control mice. It also down-regulated the expression of inflammation-related genes including monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α) and the number of infiltrated macrophages within the adipose tissue in vivo.
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Animal Model:
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Collagen-induced arthritis (CIA) mice
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Dosage:
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100 mg/kg
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Administration:
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Oral administration; twice daily; 2 weeks
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Result:
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Reduced synovial inflammation and joint destruction.
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Animal Model:
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C57BL/6J mice
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Dosage:
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100 mg/kg
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Administration:
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Oral administration; dosed (09.00 and 17.00 h); last 4 weeks
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Result:
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Improved metabolic homeostasis and suppressed the inflammation of adipose tissue in diet-induced obese mice.
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BVT 2733
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | S0209 | BVT 2733
BVT 2733 | 376640-41-4 | 5mg | 657.46元 |
| 2024/04/30 | S0209 | BVT 2733
BVT 2733 | 376640-41-4 | 25mg | 2383.47元 |
376640-41-4, BVT 2733 相关搜索:
- Inhibitors
- 药靶配体
- 小分子抑制剂，天然产物
- 小分子抑制剂
- C17H21ClN4O3S2
- 化合物BVT 2733
- 3-氯-2-甲基-N-(4-(2-(4-甲基哌嗪-1-基)-2-氧代乙基)噻唑-2-基)苯磺酰胺
- 376640-41-4
- HFD,CIA,BVT-2733,J774.1,arthritis,macrophage,collagen,inhibit,BVT2733,BVT 2733,disease,adipocyte,Inhibitor,obesity
- BVT.2733 >=98% (HPLC)
- BVT2733, >98%
- 3-CHLORO-2-METHYL-N-[4-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHYL]-1,3-THIAZOL-2-YL]BENZENESULFONAMIDE
- BENZENESULFONAMIDE, 3-CHLORO-2-METHYL-N-[4-[2-(4-METHYL-1-PIPERAZINYL)-2-OXOETHYL]-2-THIAZOLYL]-
- BVT 2733(BVT.2733)
- 3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide