网站主页 >> CAS数据库列表 >> 3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐
3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐
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- CAS号:
- 1449240-68-9
- 英文名:
- K145 (hydrochloride)
- 英文别名:
- K145(HCl);K145 HCl salt;SphK2 inhibitor;K14 (hydrochloride);K145 (hydrochloride);K145 hydrochloride >=98% (HPLC);SPHK2 INHIBITOR;K 145 HYDROCHLORIDE;K-145 HYDROCHLORIDE;3-(2-Aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione hydrochloride;3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione hydrochloride;3-(2-Aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-2,4-thiazolidinedione hydrochloride (1:1)
- 中文名:
- 3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐
- 中文别名:
- K145盐酸盐;SPHK2抑制剂(K145盐酸盐);3-(2-氨乙基)-5-(3-(4-丁氧基苯基)丙亚基)噻唑烷-2,4-二酮 盐酸盐;3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐
- CBNumber:
- CB72677063
- 分子式:
- C18H25ClN2O3S
- 分子量:
- 384.9207
- MOL File:
- 1449240-68-9.mol
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3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble20mg/mL, clear
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形态:
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powder
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颜色:
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white to beige
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3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐性质、用途与生产工艺
K145 hydrochloride 是一种选择性的,具有底物竞争性和口服活性的 SphK2 抑制剂,IC50 为 4.3 µM,Ki 为 6.4 µM。K145 hydrochloride 对 SphK1 和其他蛋白激酶没有活性。K145 hydrochloride 可诱导细胞凋亡,并具有强大的抗肿瘤活性。
IC50: 4.3 µM (SphK2)
Ki: 6.4 µM (SphK2)
K145 (0-10 µM; 24-72 hours; U937 cells) treatment significantly inhibits the growth of U937 cells in a concentration-dependent manner.
K145 (10 µM; 24 hours; U937 cells) treatment significantly induces apoptosis in U937 cells.
K145 (4-8 µM; 3 hours; U937 cells) treatment decreases the phosphorylation of ERK and Akt.
Treatment with K145 (10 µM) causes a decrease of total cellular S1P without significant effects on ceramide levels.
Cell Viability Assay
Cell Line:
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U937 cells
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Concentration:
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0 µM, 4 µM, 6 µM, 8 µM, 10 µM
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Incubation Time:
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24 hours, 48 hours, 72 hours
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Result:
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Significantly inhibited the growth of U937 cells in a concentration-dependent manner.
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Apoptosis Analysis
Cell Line:
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U937 cells
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Concentration:
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10 µM
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Incubation Time:
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24 hours
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Result:
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Significantly induced apoptosis in U937 cells.
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Western Blot Analysis
Cell Line:
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U937 cells
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Concentration:
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4 µM, 8 µM
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Incubation Time:
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3 hours
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Result:
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Phosphorylated ERK and Akt were decreased.
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K145 (50 mg/kg; oral gavage; daily; for 15 days; BALB/c-nu mice) treatment significantly inhibits the growth of U937 tumors in nude mice.
Animal Model:
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BALB/c-nu mice injected with U937 cells
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Dosage:
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50 mg/kg
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Administration:
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Oral gavage; daily; for 15 days
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Result:
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Inhibited the growth of U937 tumors at 50 mg/kg dose and no apparent toxicity was observed.
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3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐
上下游产品信息
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-15779A | 3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐 K145 hydrochloride | 1449240-68-9 | 5mg | 418元 |
2024/04/30 | HY-15779A | 3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐 K145 hydrochloride | 1449240-68-9 | 10mg | 585元 |
3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐
生产厂家
1449240-68-9, 3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐 相关搜索:
- API
- 细胞生物学试剂
- C18H24N2O3SHCl
- 3-(2-氨乙基)-5-(3-(4-丁氧基苯基)丙亚基)噻唑烷-2,4-二酮 盐酸盐
- K145盐酸盐
- SPHK2抑制剂(K145盐酸盐)
- 3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐
- 1449240-68-9
- K145 HCl salt
- K-145,K 145,ERK,K145 hydrochloride,K145,Sphingosine kinase,anti-proliferative,SphK,Akt,sphingosine,inhibit,Apoptosis,oral,SphK2,substrate-competitive,K-145 hydrochloride,Inhibitor,antitumor,apoptotic,S1P
- 3-(2-Aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione hydrochloride
- K145 hydrochloride >=98% (HPLC)
- SPHK2 INHIBITOR;K 145 HYDROCHLORIDE;K-145 HYDROCHLORIDE
- SphK2 inhibitor
- K14 (hydrochloride)
- 3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione hydrochloride
- 3-(2-Aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-2,4-thiazolidinedione hydrochloride (1:1)
- K145(HCl)
- K145 (hydrochloride)