CYM-5541
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- CAS号:
- 945128-26-7
- 英文名:
- N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
- 英文别名:
- ML249;CYM5541;CYM-5541;CID-17253208;CYM 5541(ML-249);CYM-5541;CYM 5541;ML-249;ML 249;ML249;N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide;N,N-Dicyclohexyl-5-cyclopropylisoxazole-3-carboxamide;3-Isoxazolecarboxamide, N,N-dicyclohexyl-5-cyclopropyl-;N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
- 中文名:
- CYM-5541
- 中文别名:
- CYM5541游离态;化合物CYM 5541;优选]CYM 5541;CYM 5541,S1P3受体变构激动剂;N,N-二环己基-5-环丙基异恶唑-3-甲酰胺
- CBNumber:
- CB72750683
- 分子式:
- C19H28N2O2
- 分子量:
- 316.44
- MOL File:
- 945128-26-7.mol
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CYM-5541化学性质
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沸点:
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503.1±38.0 °C(Predicted)
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密度:
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1.14±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble5mg/mL, clear (warmed)
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酸度系数(pKa):
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-2.57±0.20(Predicted)
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形态:
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powder
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颜色:
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white to beige
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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CYM-5541性质、用途与生产工艺
CYM5541 (ML249)是一种选择性的S1P3变构受体激动剂，EC50为72-132 nM。
CYM-5541 is a full agonist, able to reach the maximum level of ERK phosphorylation that is observed with S1P. CYM-5541 has an EC
50
of between 72 and 132 nM and exhibits exquisite selectivity over other S1P receptor subtypes: S1P1 EC
50
>10 μM, S1P2 EC
50
>50 μM, S1P4 EC
50
>50 μM, and S1P5 EC
50
>25 μM. CYM-5541 also shows selectivity over a large panel of protein targets, with no significant activities, in the Ricerca profiling panel of 55 GPCRs, ion channels, and transporters. CYM-5541 allowed us to identify an allosteric site where F263 is a key gate-keeper residue for its affinity and efficacy. The novel allosteric hydrophobic pocket may account for the S1P3 selectivity of CYM-5541.
CYM-5541
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101419 | CYM-5541 | | 1 mg | 300元 |
| 2024/04/30 | HY-101419 | CYM-5541
CYM-5541 | 945128-26-7 | 5mg | 720元 |
945128-26-7, CYM-5541 相关搜索:
- 合成有机化合物配体
- CYM 5541,S1P3受体变构激动剂
- 优选]CYM 5541
- N,N-二环己基-5-环丙基异恶唑-3-甲酰胺
- CYM5541游离态
- 化合物CYM 5541
- 945128-26-7
- N,N-Dicyclohexyl-5-cyclopropylisoxazole-3-carboxamide
- CYM5541,inhibit,ML-249,LPL Receptor,CYM-5541,ML 249,Inhibitor,Lysophospholipid Receptor
- 3-Isoxazolecarboxamide, N,N-dicyclohexyl-5-cyclopropyl-
- CID-17253208
- N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
- CYM-5541;CYM 5541;ML-249;ML 249;ML249
- CYM 5541(ML-249)
- N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
- N,N-Dicyclohexyl(5-cyclopropylisoxazol-3-yl)-carboxamide
- ML249
- CYM-5541
- CYM5541