NSC-624206
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- CAS号:
- 13116-77-3
- 英文名:
- NSC-624206
- 英文别名:
- NSC-624206;NSC624206,NSC-624206;N-[3-(4-chlorophenyl)-3,3-disulfanylpropyl]decan-1-aminium chloride;N-[2-[[(4-Chlorophenyl)methyl]dithio]ethyl]-1-decanamine hydrochloride;1-Decanamine, N-[2-[[(4-chlorophenyl)methyl]dithio]ethyl]-, hydrochloride (1:1)
- 中文名:
- NSC-624206
- 中文别名:
- 化合物 T12265
- CBNumber:
- CB73067566
- 分子式:
- C19H33Cl2NS2
- 分子量:
- 410.50802
- MOL File:
- 13116-77-3.mol
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NSC-624206化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble to 50 mM in DMSO and to 20 mM in ethanol
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形态:
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Powder
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NSC-624206性质、用途与生产工艺
NSC624206 是一种泛素 E1 (UBA1) 抑制剂，其 IC50 值为 ~9 μM。NSC624206 特异性地阻断泛素-硫代酯的形成，但对泛素腺化无影响。
IC50: ~9 μM (ubiquitin E1)
NSC624206 prevents in vitro ubiquitination of the cell cycle regulator p27 as well as inducing an accumulation of p27 in the HepG2 liver cancer cell line.
NSC624206 clearly reduces ubiquitin-E1 thioesters in a concentration-dependent manner with an IC
50
of 13 μM.
NSC624206 (10 nM-10 μM; 24 hours) induces accumulation of p27 in cells.
Western Blot Analysis
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Cell Line:
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Kip16 cells
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Concentration:
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10 nM-10 μM
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Incubation Time:
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24 hours
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Result:
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Induced accumulation of p27.
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NSC-624206
上下游产品信息
上游原料
下游产品
13116-77-3, NSC-624206 相关搜索:
- C19H32ClNS2HCl
- 化合物 T12265
- 13116-77-3
- 1-Decanamine, N-[2-[[(4-chlorophenyl)methyl]dithio]ethyl]-, hydrochloride (1:1)
- NSC624206,NSC-624206
- N-[2-[[(4-Chlorophenyl)methyl]dithio]ethyl]-1-decanamine hydrochloride
- N-[3-(4-chlorophenyl)-3,3-disulfanylpropyl]decan-1-aminium chloride
- NSC-624206