934369-14-9
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- CAS号:
- 934369-14-9
- 英文名:
- TY-52156
- 英文别名:
- TY-52156;TY52156;TY 52156;N,N'-bis(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidhydrazide;N,N'-bis(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidhydrazide;N'-(4-chloroanilino)-N-(4-chlorophenyl)-3,3-dimethyl-2-oxo-butanamidine;N-(4-chlorophenyl)-N'-(4-chlorophenylamino)-3,3-dimethyl-2-oxobutanamidine;N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide;Inhibitor,LPL Receptor,TY-52156,inhibit,Lysophospholipid Receptor,TY 52156,TY52156;Butanimidic acid, N-(4-chlorophenyl)-3,3-dimethyl-2-oxo-, 2-(4-chlorophenyl)hydrazide
- 中文名:
- 934369-14-9
- 中文别名:
- 化合物TY-52156;TY-52156,新型S1P3受体拮抗剂;N,N'-双(4-氯苯基)-3,3-二甲基-2-氧代丁烷亚胺酰肼;N,N'-双(4-氯苯基)-3,3-二甲基-2-氧代丁烷亚胺酰肼
- CBNumber:
- CB73122351
- 分子式:
- C18H19Cl2N3O
- 分子量:
- 364.27
- MOL File:
- 934369-14-9.mol
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934369-14-9化学性质
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熔点:
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90-91 °C
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沸点:
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62-69 °C(Press: 20 Torr)
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密度:
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1.22±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C(protect from light)
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溶解度:
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≥92.8 mg/mL in DMSO; ≥94.6 mg/mL in EtOH; insoluble in H2O
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形态:
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crystalline solid
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酸度系数(pKa):
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0.99±0.50(Predicted)
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934369-14-9性质、用途与生产工艺
TY-52156 是一种有效、选择性的 S1P3 受体拮抗剂,Ki 值为 110 nM。
TY-52156 inhibits the S1P
3
receptor-dependent increase in [Ca
2+
]
i
.
TY-52156 shows submicromolar potency and a high degree of selectivity for S1P
3
receptor.
TY-52156 (10 μM; 10 min) inhibits S1P-induced p44/p42 MAPK phosphorylation.
Western Blot Analysis
Cell Line:
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Chinese hamster ovary K1 cells
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Concentration:
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10 μM
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Incubation Time:
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10 min
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Result:
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Inhibited S1P-induced p44/p42 MAPK phosphorylation.
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TY-52156 (10 mg/kg, 30 mg/kg; p.o.) suppresses S1P
3
receptor-induced bradycardia after oral administration in vivo.
Animal Model:
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Male SD rats (290–340 g)
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Dosage:
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10 mg/kg, 30 mg/kg
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Administration:
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Oral administration
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Result:
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Inhibited S1P
3
receptor-induced bradycardia after oral administration in vivo.
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934369-14-9
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-19736 | 934369-14-9 TY-52156 | 934369-14-9 | 5mg | 700元 |
2024/04/30 | HY-19736 | 934369-14-9 TY-52156 | 934369-14-9 | 10mg | 1100元 |
934369-14-9, 934369-14-9 相关搜索:
- 合成有机化合物配体
- N,N'-双(4-氯苯基)-3,3-二甲基-2-氧代丁烷亚胺酰肼
- TY-52156,新型S1P3受体拮抗剂
- N,N'-双(4-氯苯基)-3,3-二甲基-2-氧代丁烷亚胺酰肼
- 化合物TY-52156
- 934369-14-9
- N,N'-bis(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidhydrazide
- Inhibitor,LPL Receptor,TY-52156,inhibit,Lysophospholipid Receptor,TY 52156,TY52156
- N,N'-bis(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidhydrazide
- N'-(4-chloroanilino)-N-(4-chlorophenyl)-3,3-dimethyl-2-oxo-butanamidine
- Butanimidic acid, N-(4-chlorophenyl)-3,3-dimethyl-2-oxo-, 2-(4-chlorophenyl)hydrazide
- N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide
- TY52156;TY 52156
- N-(4-chlorophenyl)-N'-(4-chlorophenylamino)-3,3-dimethyl-2-oxobutanamidine
- TY-52156