200050-59-5
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- CAS号:
- 200050-59-5
- 英文名:
- L-771688
- 英文别名:
- L-771688;L771688,L 771688;5-Pyrimidinecarboxylic acid, 6-(3,4-difluorophenyl)-1,2,3,6-tetrahydro-4-(methoxymethyl)-2-oxo-1-[[[3-[4-(2-pyridinyl)-1-piperidinyl]propyl]amino]carbonyl]-, methyl ester, (6S)-
- 中文名:
- 200050-59-5
- 中文别名:
- 化合物 T15688
- CBNumber:
- CB73339669
- 分子式:
- C28H33F2N5O5
- 分子量:
- 557.59
- MOL File:
- 200050-59-5.mol
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200050-59-5化学性质
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密度:
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1.274±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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10.90±0.70(Predicted)
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200050-59-5性质、用途与生产工艺
L-771688 是一个选择性 α1A-Adrenoceptor 受体拮抗剂， Ki 值为 0.43±0.02 nM。
Ki: 0.43±0.02 nM (α1A-Adrenoceptor)
Specific [
3
H]L-771688 binding to cloned human α1A-Adrenoceptors is inhibited with high potency by subtype selective compounds, GG818 (K
i
=0.026±0.002 nM) and L-771688 (K
i
=0.052±0.008 nM) and subtype non-selective α1-adrenoceptor antagonists, prazosin (K
i
=0.088±0.0.032 nM) and terazosin (K
i
=1.8±0.65 nM). The relative amount of [
3
H]L-771688 (0.5 nM) binding in various rat tissue membranes is highest in submaxillary gland (9.5 pmol/g tissue), followed by brain (5.8 pmol/g tissue), vas deferens (4.3 pmol/g tissue), kidney (3.4 pmol/g tissue), heart (1.5 pmol/g tissue), urethra (1.1 pmol/g tissue) and prostate (0.88 pmol/g tissue). In contrast, low specific [
3
H]L-771688 binding is observed in rat urinary bladder (0.55 pmol/g tissue), liver (0.44 pmol/g tissue), aorta (0.11 pmol/g tissue) and spleen (0.11 pmol/g tissue).
200050-59-5
上下游产品信息
上游原料
下游产品
200050-59-5, 200050-59-5 相关搜索:
- C28H33F2N5O5
- 化合物 T15688
- 200050-59-5
- L771688,L 771688
- 5-Pyrimidinecarboxylic acid, 6-(3,4-difluorophenyl)-1,2,3,6-tetrahydro-4-(methoxymethyl)-2-oxo-1-[[[3-[4-(2-pyridinyl)-1-piperidinyl]propyl]amino]carbonyl]-, methyl ester, (6S)-
- L-771688