SR57227盐酸盐
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- CAS号:
- 77145-61-0
- 英文名:
- SR 57227 HYDROCHLORIDE
- 英文别名:
- cm57227;sr57227a;CM-57277;SR57227HCl;SR 57227 HYDROCHLORIDE;SR 57227A HYDROCHLORIDE;4-AMINO-1-(6-CHLORO-2-PYRIDYL)-PIPERIDINE HYDROCHLORIDE;1-(6-CHLORO-2-PYRIDINYL)-4-PIPERIDINAMINE HYDROCHLORIDE;1-(6-chloropyridin-2-yl)piperidin-4-amine hydrochloride;4-amino-1-(6-chloro-2-pyridyl)piperidinemonohydrochloride
- 中文名:
- SR57227盐酸盐
- 中文别名:
- SR57227盐酸盐;1-(6-氯吡啶-2-基)哌啶-4-胺盐酸盐;4-氨基-1-(6-氯-2-吡啶基)哌啶盐酸盐
- CBNumber:
- CB7365504
- 分子式:
- C10H15Cl2N3
- 分子量:
- 248.15
- MOL File:
- 77145-61-0.mol
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SR57227盐酸盐化学性质
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储存条件:
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Store at RT
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溶解度:
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H2O: 9 mg/mL, soluble
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形态:
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solid
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颜色:
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white
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SR57227盐酸盐性质、用途与生产工艺
SR 57227A 是具有口服活性的 5-HT3 受体的一种选择性激动剂, 可透过血脑屏障。SR 57227A 对大鼠皮质膜和整个 NG 108-15 细胞或其膜上 5-HT3 受体结合位点的亲和力 (IC50) 在 2.8~250 nM。具有抗抑郁作用。
SR 57227A binds to 5-HT3 receptors labelled with [3H]S-zacopride with an affinity (K
i
) of 115 nM in rat cerebral cortex, 150 nM in NG 108-15 cell membranes and 103 nM in whole NG 108-15 cell.
SR 57227A (1-30 mg/kg; i.p.) dose-dependently reduces immobility time in the forced swimming test with an ED
50
value for this effect of 14.2 mg/kg.
In the forced swimming test, SR 57227A dose-dependently reduces the duration of immobility in rats after i.p. administration. (ED
50
=7.6 mg/kg i.p. in rats.) SR 57227A is also active in both species after oral administration. In a time-course study in mice, SR 57227A (20 mg/kg p.o.) produces a significant effect lasting 6 hours. SR 57227A (1 and 3 mg/kg i.p.) reduces the elevation of the escape failures in the learned helplessness model in rats by 50-60% on the last two days of the avoidance task, and reduces isolation-induced aggressivity in mice by 50 to 85%, an effect which is antagonised by Zacopride (1 mg/kg i.p.).
SR57227盐酸盐
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-102064 | SR 57227A | | 5 mg | 875元 |
| 2024/04/30 | HY-102064 | SR57227盐酸盐
SR 57227A | 77145-61-0 | 10mg | 1400元 |
77145-61-0, SR57227盐酸盐 相关搜索:
- Serotonin receptor
- 药靶配体
- C10H15N3Cl2
- C10H15Cl2N3HCl
- C10H14ClN3HCl
- 1-(6-氯吡啶-2-基)哌啶-4-胺盐酸盐
- SR57227盐酸盐
- 4-氨基-1-(6-氯-2-吡啶基)哌啶盐酸盐
- 77145-61-0
- immobility,barrier,SR 57227A,Serotonin Receptor,cell,brain,5-HT Receptor,Inhibitor,5-hydroxytryptamine Receptor,anti-depressant,inhibit,blood,NG 108-15
- cm57227
- 4-amino-1-(6-chloro-2-pyridyl)piperidinemonohydrochloride
- 1-(6-chloro-2-pyridinyl)-4-piperidinaminmonohydrochloride
- 1-(6-chloro-2-pyridinyl)-4-piperidinaminemonohydrochloride
- 1-(6-chloropyridin-2-yl)piperidin-4-amine hydrochloride
- CM-57277
- SR57227HCl
- SR 57227 HYDROCHLORIDE
- SR 57227A HYDROCHLORIDE
- 4-AMINO-1-(6-CHLORO-2-PYRIDYL)-PIPERIDINE HYDROCHLORIDE
- 1-(6-CHLORO-2-PYRIDINYL)-4-PIPERIDINAMINE HYDROCHLORIDE
- sr57227a