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1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride
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- CAS号:
- 1164469-60-6
- 英文名:
- 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride
- 英文别名:
- KT-611 hydrochloride;Emorfazone Impurity 3;BM-15275 hydrochloride;1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride;BM-15275,BM15275,canine,prostatic,Naftopidil,prostate,hyperplasia,inhibit,Inhibitor,Naftopidil hydrochloride,KT-611,Adrenergic Receptor,KT611,KT 611,pressure,BM 15275,Beta Receptor
- 中文名:
- 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride
- 中文别名:
- 萘哌地尔盐酸盐;NAFTOPIDIL HYDROCHLORIDE,Α1拮抗剂
- CBNumber:
- CB73845715
- 分子式:
- C24H29ClN2O3
- 分子量:
- 428.95166
- MOL File:
- 1164469-60-6.mol
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1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 10 mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL; DMSO: 3 mg/mL
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形态:
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A crystalline solid
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1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride性质、用途与生产工艺
Naftopidil hydrochloride (KT-611 hydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力 Ki 值分别为 3.7 nM、20 nM、1.2 nM，具有抗增殖作用。Naftopidil hydrochloride 可用于前列腺增生的研究。
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Alpha-1A adrenergic receptor
3.7 nM (Ki)
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Alpha-1B adrenergic receptor
20 nM (Ki)
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Alpha-1D adrenergic receptor
1.2 nM (Ki)
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Naftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma.
Naftopidil hydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC.
Naftopidil hydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
Cell Proliferation Assay
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Cell Line:
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PCa cells, PrSC
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Concentration:
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10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC)
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Incubation Time:
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3 days
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Result:
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Exhibited growth inhibitory effects on PCa cells and PrSC in dose-dependent manners.
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Western Blot Analysis
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Cell Line:
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PCa cells, PrSC
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Concentration:
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50 μM (E9 cells), 25 μM (PrSC)
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Incubation Time:
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48 hours
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Result:
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Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
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Naftopidil hydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model.
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Animal Model:
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Male athymic mice(7-8 weeks), with E9+PrSC xenograft
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Dosage:
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10 mg/kg
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Administration:
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Oral administration, daily, for 28 days
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Result:
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Decreased tumor weights.
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1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride
上下游产品信息
上游原料
下游产品
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride
生产厂家
1164469-60-6, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride 相关搜索:
- 药靶配体
- NAFTOPIDIL HYDROCHLORIDE,Α1拮抗剂
- 萘哌地尔盐酸盐
- 1164469-60-6
- Emorfazone Impurity 3
- BM-15275,BM15275,canine,prostatic,Naftopidil,prostate,hyperplasia,inhibit,Inhibitor,Naftopidil hydrochloride,KT-611,Adrenergic Receptor,KT611,KT 611,pressure,BM 15275,Beta Receptor
- KT-611 hydrochloride
- BM-15275 hydrochloride
- 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride