焦脱镁叶绿酸Α甲酯
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- CAS号:
- 6453-67-4
- 英文名:
- MPP A
- 英文别名:
- MPP A;PMPCA;INPP5E;KIAA0123;Nsc267052;Chlorophyll Impurity 5;Methyl pyropheophorbide a;Methyl pyrophaeophorbide a;Methyl carbamic pyrophyllate a;PYROPHEOPHORBIDE A METHYL ESTER
- 中文名:
- 焦脱镁叶绿酸Α甲酯
- 中文别名:
- 叶绿素杂质5;总叶绿素杂质5;焦脱镁叶绿酸Α甲酯;焦脱镁叶绿酸Α甲酯;焦脱镁叶绿酸A甲酯杂质;焦脱镁叶绿酸-ALPHA 甲酯
- CBNumber:
- CB7713107
- 分子式:
- C34H36N4O3
- 分子量:
- 548.67
- MOL File:
- 6453-67-4.mol
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焦脱镁叶绿酸Α甲酯化学性质
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沸点:
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937.4±65.0 °C(Predicted)
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密度:
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1.219±0.06 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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Chloroform (Slightly), Methanol (Slightly, Heated)
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形态:
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Solid
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颜色:
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Black
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稳定性:
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Light Sensitive
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焦脱镁叶绿酸Α甲酯性质、用途与生产工艺
Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester)，叶绿素 a 的衍生物，是一种有效的光敏剂，可用于癌症的光动力疗法 (PDT)。Methyl pyropheophorbide-a 具有光动力学活性，可以诱导细胞凋亡并抑制肿瘤的生长。
Pyropheophorbide-a methyl ester (2 μM; 12 h) inhibits the cell cycle progression from the G0/G1-phases and induces apoptosis at the light dosage of 55.6 kJ/m
2
in PC-3M cells.
Pyropheophorbide-a methyl ester (0.2-15 μM; 20 h) has no significant dark cytotoxicity in NCI-h446 cells.
Pyropheophorbide-a methyl ester (0.1-15 μM; 20 h) mediates a dose-dependent photocytotoxicity in the NCI-h446 cells.
Pyropheophorbide-a methyl ester (2-4 μM; 0-24 h) induces apoptosis of NCI-h446 cells in a time-dependent manner.
Pyropheophorbide-a methyl ester (0.5-4 μM; 0-20 h) shows a photocytotoxicity in PC-3M cells.
Apoptosis Analysis
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Cell Line:
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PC-3M cells
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Concentration:
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2 μM
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Incubation Time:
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12 h
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Result:
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Apoptosis rate was about 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 h posttreatment, respectively under the conditions of LC
75
(2 μM+55.6 kJ/m
2
).
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Pyropheophorbide-a methyl ester (15 mg/kg; tail vein and topical injection) inhibits the growth of PC-3M tumors in mice.
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Animal Model:
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Male BALB/c nude mice (6-8 weeks, 16-20 g) bearing PC-3M tumor
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Dosage:
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15 mg/kg
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Administration:
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Tail vein injection and topical injection
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Result:
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The tumor volume and the weight inhibition rate were 46.78%, 41.84% in tail vein injection group and 78.66%, 72.07% in topical injection group, respectively.
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焦脱镁叶绿酸Α甲酯
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-137473 | 焦脱镁叶绿酸Α甲酯
Methyl pyropheophorbide-a | 6453-67-4 | 5 mg | 900元 |
| 2024/04/30 | HY-137473 | 焦脱镁叶绿酸Α甲酯
Methyl pyropheophorbide-a | 6453-67-4 | 25 mg | 2800元 |
6453-67-4, 焦脱镁叶绿酸Α甲酯 相关搜索:
- Porphyrins
- Natural Porphyrins and Derivitives
- C34H36N4O3
- 总叶绿素杂质5
- 焦脱镁叶绿酸Α甲酯
- 叶绿素杂质5
- 焦脱镁叶绿酸A甲酯杂质
- 焦脱镁叶绿酸-ALPHA 甲酯
- 焦脱镁叶绿酸Α甲酯
- 6453-67-4
- MPPa (Methyl pyropheophorbide-a)
- Methyl carbamic pyrophyllate a
- 3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-, methyl ester, (3S,4S)-
- Chlorophyll Impurity 5
- Nsc267052
- PMPCA
- Mitochondrial-processing peptidase subunit alpha
- KIAA0123
- INPP5E
- ANTI-PMPCA (C-TERM) antibody produced in rabbit
- Pyropheophorbide-alpha methyl ester
- Methyl-13-decarboxy-methyl phaeophorbide-a
- Methyl pyropheophorbide a
- Methyl pyrophaeophorbide a
- 9-Ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxophorbine-3-propanoicacid meth
- 3-Phorbinepropionic acid, 14-ethyl-4,8,13,18-tetramethyl-20-oxo-9-vinyl-, methyl ester
- 3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-, methyl ester, (3S-trans)-
- PYROPHEOPHORBIDE A METHYL ESTER
- MPP A
- Pyropheophorbide α Methyl Ester
- 9-Ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxophorbine-3-propanoi