羟基伊曲康唑(伊曲康唑代谢物)
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- CAS号:
- 112559-91-8
- 英文名:
- HYDROXY ITRACONAZOLE
- 英文别名:
- R 63373;HYDROXY ITRACONAZOLE;Itraconazole Impurity 1;2H6]-Hydroxyitraconazole;Ketoconazole Impurity 36;Itraconazole 2-Hydroxy Metabolite;Hydroxy Itraconazole (10mM in DMSO);Itraconazole metabolite Hydroxy Itraconazole;Itraconazole Impurity 8(Hydroxy Itraconazole);Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole
- 中文名:
- 羟基伊曲康唑(伊曲康唑代谢物)
- 中文别名:
- 羟基曲康唑;羟基四康唑;羟基伊曲康唑;依曲康唑杂质;酮康唑杂质36;伊曲康唑杂质1;伊曲康唑杂质8;伊曲康唑代谢物;2H6]-羟基曲康唑;伊曲康唑2-羟基代谢物
- CBNumber:
- CB8173597
- 分子式:
- C35H38Cl2N8O5
- 分子量:
- 721.63
- MOL File:
- 112559-91-8.mol
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羟基伊曲康唑(伊曲康唑代谢物)化学性质
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熔点:
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76-78°C
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沸点:
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884.7±75.0 °C(Predicted)
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密度:
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1.44±0.1 g/cm3(Predicted)
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储存条件:
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-20°C Freezer
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溶解度:
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Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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14.72±0.20(Predicted)
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颜色:
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White to Pale Beige
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羟基伊曲康唑(伊曲康唑代谢物)性质、用途与生产工艺
Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) 是 Itraconazole (ITZ) 的活性代谢物,Itraconazole 是一种三唑类抗真菌剂。
Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ). Although Hydroxy Itraconazole is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and Hydroxy Itraconazole have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration.
The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view.
羟基伊曲康唑(伊曲康唑代谢物)
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-12772 | 羟基伊曲康唑(伊曲康唑代谢物) Hydroxy Itraconazole | 112559-91-8 | 1mg | 1900元 |
2024/04/30 | HY-12772 | 羟基伊曲康唑(伊曲康唑代谢物) Hydroxy Itraconazole | 112559-91-8 | 5mg | 7500元 |
112559-91-8, 羟基伊曲康唑(伊曲康唑代谢物) 相关搜索:
2,4-二氢-4-[[4-(4-羟基苯基)-1-哌嗪基]苯基]-2-(1-甲基丙基)-3H-1,2,4-三氮唑-3-酮 2,4-二氢-4-[4-[4-(4-甲氧基苯基)-1-哌嗪基]苯基]-2-(1-甲基丙基)-3H-1,2,4-三唑-3-酮 4-(4-(4-甲氧基苯基)-1-哌嗪基)苯胺 伊曲康唑杂质F ItraconazoleImpurity34 伊曲康唑杂质33 伊曲康唑杂质E 伊曲康唑 酮基伊曲康唑 伊曲康唑杂质17 伊曲康唑杂质27 伊曲康唑杂质37 伊曲康唑杂质19 伊曲康唑杂质C 伊曲康唑杂质B cis-甲磺酸-[2-(2,4-二氯苯基)-2-(1H-1,2,4-三唑-1-基甲基)-1,3-二氧戊环-4-基]甲酯 伊曲康唑杂质15 顺式溴代酯
- Isotopically Labeled Pharmaceutical Reference Standard
- metabolites
- Isotooe labelled metabolites
- Various Metabolites and Impurities
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- 临床检测标准物质
- 抑制剂
- 对照品-杂质对照品
- C35H38Cl2N8O5
- C35H40Cl2N8O4
- 羟基伊曲康唑(非对映体混合物)
- 羟基四康唑
- 酮康唑杂质36
- 伊曲康唑杂质8(羟基伊曲康唑)
- 羟基曲康唑
- 2H6]-羟基曲康唑
- 伊曲康唑杂质8
- 依曲康唑杂质
- 伊曲康唑杂质1
- 羟基伊曲康唑(伊曲康唑代谢物)
- 羟基伊曲康唑
- 伊曲康唑2-羟基代谢物
- 伊曲康唑代谢物
- 112559-91-8
- Ketoconazole Impurity 36
- 2H6]-Hydroxyitraconazole
- Hydroxy ItraconazoleQ: What is
Hydroxy Itraconazole Q: What is the CAS Number of
Hydroxy Itraconazole Q: What is the storage condition of
Hydroxy Itraconazole Q: What are the applications of
Hydroxy Itraconazole
- Hydroxy Itraconazole D8Q: What is
Hydroxy Itraconazole D8 Q: What is the CAS Number of
Hydroxy Itraconazole D8 Q: What is the storage condition of
Hydroxy Itraconazole D8 Q: What are the applications of
Hydroxy Itraconazole D8
- Hydroxy Itraconazole (10mM in DMSO)
- 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one
- Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole
- Itraconazole Impurity 1
- Itraconazole Impurity 8(Hydroxy Itraconazole)
- Itraconazole metabolite Hydroxy Itraconazole
- Itraconazole 2-Hydroxy Metabolite
- 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-Methylpropyl)-
- R 63373
- 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one
- 3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-
- HYDROXY ITRACONAZOLE