替仑西平二盐酸盐
|
|
|
- CAS号:
- 147416-96-4
- 英文名:
- TELENZEPINE DIHYDROCHLORIDE
- 英文别名:
- TelenzepineHydrochloride;Telenzepine dihydrochloide;TELENZEPINE DIHYDROCHLORIDE;JTQJFSQQHGPLOX-UHFFFAOYSA-N;Telenzepine hydrate dihydrochloride;TELENZEPINE DIHYDROCHLORIDE SELECTIVE M1 MUSCARIN;4,9-Dihydro-3-methyl-4-((4-methyl-1-piperazinyl)acetyl)-(10H);4,9-Dihydro-3-methyl-4-((4-methyl-1-piperazinyl)acetyl)-(10H)thieno[3,4-b][1,5]benzodiazepin-10-onedihydrochloride;4,9-DIHYDRO-3-METHYL-4-[(4-METHYL-1-PIPERAZINYL)ACETYL]-10H-THIENO[3,4-B][1,5] BENZODIAZEPIN-10-ONE DIHYDROCHLORIDE
- 中文名:
- 替仑西平二盐酸盐
- 中文别名:
- 替仑西平二盐酸盐;化合物 T23452
- CBNumber:
- CB8218386
- 分子式:
- C19H22N4O2S
- 分子量:
- 370.47
- MOL File:
- 147416-96-4.mol
|
|
|
替仑西平二盐酸盐化学性质
-
储存条件:
-
Store at RT
-
|
-
溶解度:
-
H2O: >10 mg/mL
-
|
-
形态:
-
solid
-
|
-
颜色:
-
white
-
|
-
水溶解性:
-
Soluble to 100 mM in water
-
|
替仑西平二盐酸盐性质、用途与生产工艺
Telenzepine dihydrochloride 是一种选择性和具有口服活性的毒蕈碱 M1 受体拮抗剂，Ki 为 0.94 nM。Telenzepine dihydrochloride 抑制胃酸分泌并具有抗溃疡作用。
Ki: 0.94 nM (Muscarinic M1 receptor), 17.8 nM (Muscarinic M2 receptor)
At submicromolar concentrations (100 nM), Telenzepine abolishes responses to either muscarine or the muscarinic component of the acetylcholine response. The excitatory effect of muscarine at postsynaptic M1 receptors is dose dependently inhibited by Telenzepine (0.1-1000 nM) at concentrations.
The threshold dose of Telenzepine as an antagonist of the muscarinic depolarization in AH/type 2 neurons is in the range of 0.1-1 nM. The IC
50
of Telenzepine needed to abolish the response is 8.5 nM.
Intravenous Telenzepine potently inhibits gastric acid secretion in the Ghosh-Schild rat (carbachol-stimulated), the chronic fistula rat (basal secretion), or, both intravenously and orally, in the modified Shay rat.
Telenzepine (2.7 μmol/kg; orally) treatment shows significantly longer duration antiulcer effects in the modified Shay rat.
替仑西平二盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-B1789A | Telenzepine dihydrochloride | | 5 mg | 950元 |
| 2024/04/30 | HY-B1789A | Telenzepine dihydrochloride | | 10 mg | 1500元 |
147416-96-4, 替仑西平二盐酸盐 相关搜索:
- Acetylcholine receptor
- 药靶配体
- C19H22N4O2S
- C19H22N4O2S2HCl
- C19H24Cl2N4O2S
- 化合物 T23452
- 替仑西平二盐酸盐
- 147416-96-4
- TelenzepineHydrochloride
- JTQJFSQQHGPLOX-UHFFFAOYSA-N
- 4,9-Dihydro-3-methyl-4-((4-methyl-1-piperazinyl)acetyl)-(10H)
- Telenzepine hydrate dihydrochloride
- Telenzepine dihydrochloide
- 4,9-Dihydro-3-methyl-4-((4-methyl-1-piperazinyl)acetyl)-(10H)thieno[3,4-b][1,5]benzodiazepin-10-onedihydrochloride
- TELENZEPINE DIHYDROCHLORIDE SELECTIVE M1 MUSCARIN
- TELENZEPINE DIHYDROCHLORIDE
- 4,9-DIHYDRO-3-METHYL-4-[(4-METHYL-1-PIPERAZINYL)ACETYL]-10H-THIENO[3,4-B][1,5] BENZODIAZEPIN-10-ONE DIHYDROCHLORIDE