AS 1269574
|
|
|
- CAS号:
- 330981-72-1
- 英文名:
- AS 1269574
- 英文别名:
- AS126957;AS 1269574;AS-1269574
(AS1269574);2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol;2-[[2-(4-BroMophenyl)-6-Methyl-4-pyrinidinyl]aMino]ethanol;2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol;Ethanol, 2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]-;TRP Channel,G Protein-Coupled Receptor 119,secretion,Inhibitor,type,AS1269574,cation,diabetes,insulin,inhibit,Transient receptor potential channels,glucose,GPR119,channels,AS-1269574
- 中文名:
- AS 1269574
- 中文别名:
- 化合物AS 1269574;AS 1269574,GPR119受体激动剂;2-((2-(4-溴苯基)-6-甲基嘧啶-4-基)氨基)乙醇
- CBNumber:
- CB82535661
- 分子式:
- C13H14BrN3O
- 分子量:
- 308.17
- MOL File:
- 330981-72-1.mol
|
|
|
AS 1269574化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
solution in ethanol
-
|
AS 1269574性质、用途与生产工艺
AS1269574 是一种有效的，具有口服活性的 GPR119 激动剂，在表达人 GPR119 的 HEK293 细胞中 EC50 为 2.5 μM。AS1269574 激活 TRPA1 阳离子通道，刺激胰高血糖素样肽-1 (GLP-1) 分泌。AS1269574 仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。AS1269574 对 2 型糖尿病研究具有潜力。
AS1269574 sgnificantly reduced the blood glucose AUC after 2 h (AUC
0-2h
) of administration.
|
Animal Model:
|
Eight-week-old ICR mice
|
|
Dosage:
|
100 mg/kg
|
|
Administration:
|
P.o.
|
|
Result:
|
Sgnificantly reduced the blood glucose AUC after 2 h (AUC
0-2h
) of administration. Similarly, plasma insulin AUC
0-2h
was significantly higher in the mice.
|
AS 1269574
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-107535 | AS 1269574
AS1269574 | 330981-72-1 | 10mg | 1300元 |
| 2024/04/30 | HY-107535 | AS 1269574
AS1269574 | 330981-72-1 | 50mg | 4000元 |
330981-72-1, AS 1269574 相关搜索:
- Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
- 合成有机化合物配体
- AS 1269574,GPR119受体激动剂
- 2-((2-(4-溴苯基)-6-甲基嘧啶-4-基)氨基)乙醇
- 化合物AS 1269574
- 330981-72-1
- TRP Channel,G Protein-Coupled Receptor 119,secretion,Inhibitor,type,AS1269574,cation,diabetes,insulin,inhibit,Transient receptor potential channels,glucose,GPR119,channels,AS-1269574
- Ethanol, 2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]-
- 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol
- AS126957
- AS-1269574
(AS1269574)
- 2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol
- 2-[[2-(4-BroMophenyl)-6-Methyl-4-pyrinidinyl]aMino]ethanol
- AS 1269574