CID 5951923
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- CAS号:
- 749872-43-3
- 英文名:
- CID 5951923
- 英文别名:
- AC1NZ6UQ;CID 5951923;KLF5 Inhibitor, CID 5951923;KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem;[2-[(1,1-Dioxothiolan-3-yl)-methylamino]-2-oxoethyl] (E)-3-(3-nitrophenyl)prop-2-enoate;2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl 3-(3-nitrophenyl)acrylate;3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-me;2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)amino]-2-oxoethyl (E)-3-(3-nitrophenyl)prop-2-enoate;3-(3-Nitrophenyl)-2-propenoic Acid 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)aMino]-2-oxoethyl Ester;3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-methyl ester
- 中文名:
- CID 5951923
- 中文别名:
- 化合物 T22667;化合物CID 5951923;3-(3-硝基苯基)-2-丙烯酸2-[甲基(四氢-1,1-二氧代-3-噻吩基)氨基] -2-氧代乙基酯
- CBNumber:
- CB82574686
- 分子式:
- C16H18N2O7S
- 分子量:
- 382.39
- MOL File:
- 749872-43-3.mol
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CID 5951923化学性质
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沸点:
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646.9±55.0 °C(Predicted)
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密度:
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1.43±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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DMSO: soluble10mg/mL (clear solution)
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酸度系数(pKa):
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-1.40±0.20(Predicted)
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形态:
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powder
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颜色:
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white to beige
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CID 5951923性质、用途与生产工艺
CID 5951923是一种有效的 Krüppel-like factor 5 (KLF5) 抑制剂，IC50 值为 603 nM，CID 5951923 可在体外抑制癌细胞的增殖。
CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner.
CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY
1068
, and downregulated EGR1.
CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells.
Cell Viability Assay
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Cell Line:
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DLD-1 and IEC-6 cells
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Concentration:
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0.001, 0.01, 0.1, 1, 10, 100 μM
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Incubation Time:
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48 h
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Result:
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Inhibited proliferation of DLD-1 cells with an IC
50
of 1.6 μM.
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CID 5951923
上下游产品信息
上游原料
下游产品
749872-43-3, CID 5951923 相关搜索:
- Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
- 化合物CID 5951923
- 化合物 T22667
- 3-(3-硝基苯基)-2-丙烯酸2-[甲基(四氢-1,1-二氧代-3-噻吩基)氨基] -2-氧代乙基酯
- 749872-43-3
- 2-Propenoic acid, 3-(3-nitrophenyl)-, 2-[methyl(tetrahydro-1,1-dioxido-3-thienyl)amino]-2-oxoethyl ester
- Krüppel-like factor,CID-5951923,CID5951923,KLF5,inhibit,cancer,factor,KLF,transcription,Inhibitor,Krüppel-like,CID 5951923
- 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl 3-(3-nitrophenyl)acrylate
- 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)amino]-2-oxoethyl (E)-3-(3-nitrophenyl)prop-2-enoate
- KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem
- 3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-methyl ester
- KLF5 Inhibitor, CID 5951923
- 3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-me
- AC1NZ6UQ
- [2-[(1,1-Dioxothiolan-3-yl)-methylamino]-2-oxoethyl] (E)-3-(3-nitrophenyl)prop-2-enoate
- 3-(3-Nitrophenyl)-2-propenoic Acid 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)aMino]-2-oxoethyl Ester
- CID 5951923