GLABRESCIONE B
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- CAS号:
- 65893-94-9
- 英文名:
- Glabrescione B
- 英文别名:
- GlaB;Glabrescione B;Glabrescione B
(GlaB);3-[3,4-bis-(3-methyl-but-2-enyloxy)-phenyl]-5,7-dimethoxy-chromen-4-one;4H-1-Benzopyran-4-one, 3-[3,4-bis[(3-methyl-2-buten-1-yl)oxy]phenyl]-5,7-dimethoxy-
- 中文名:
- GLABRESCIONE B
- 中文别名:
- CBNumber:
- CB83255382
- 分子式:
- C27H30O6
- 分子量:
- 450.52
- MOL File:
- 65893-94-9.mol
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GLABRESCIONE B化学性质
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沸点:
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608.0±55.0 °C(Predicted)
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密度:
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1.142±0.06 g/cm3(Predicted)
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GLABRESCIONE B性质、用途与生产工艺
Glabrescione B 是第一个结合 Hedgehog (Hh) 调节剂 Gli1 并通过干扰 Gli1-DNA 相互作用而削弱其活性的化合物。Glabrescione B 抑制 Hedgehog 依赖性肿瘤细胞的生长,抑制肿瘤源性干细胞的自我更新能力和克隆能力。
Glabrescione B (5 μM; 24-72 hours) inhibits the growth of Gli-dependent basal cell carcinoma.
Glabrescione B (1-10 μM; 24-48 hours) decreases Gli1 mRNA expression levels.
Cell Proliferation Assay
Cell Line:
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ASZ001 BCC cells
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Concentration:
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5 μM
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Incubation Time:
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24-72 hours
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Result:
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Basal cell carcinoma cell proliferation was impaired.
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Western Blot Analysis
Cell Line:
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ASZ001 BCC cells
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Concentration:
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1-10 μM
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Incubation Time:
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24-48 hours
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Result:
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Gli1 mRNA expression levels was decreased.
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Animal Model:
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Female NOD/SCID mice (ASZ001 BCC allografts)
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Dosage:
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100 μmol/kg
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Administration:
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I.p.; every second day for 18 days
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Result:
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A significant reduction of tumor growth as well as Gli1 mRNA levels was observed.
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GLABRESCIONE B
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-122590 | Glabrescione B | | 1 mg | 2045元 |
2024/04/30 | HY-122590 | Glabrescione B | 65893-94-9 | 5mg | 4500元 |
65893-94-9, GLABRESCIONE B 相关搜索:
- 65893-94-9
- 4H-1-Benzopyran-4-one, 3-[3,4-bis[(3-methyl-2-buten-1-yl)oxy]phenyl]-5,7-dimethoxy-
- GlaB
- 3-[3,4-bis-(3-methyl-but-2-enyloxy)-phenyl]-5,7-dimethoxy-chromen-4-one
- Glabrescione B
(GlaB)
- Glabrescione B