R162
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- CAS号:
- 64302-87-0
- 英文名:
- R162
- 英文别名:
- R162, >98%;R162;R-162;R 162;R162,inhibit,R-162,Inhibitor,R 162;2-Allyl-1-hydroxy-9,10-anthraquinone;9,10-Anthracenedione, 1-hydroxy-2-(2-propen-1-yl)-
- 中文名:
- R162
- 中文别名:
- 化合物R162;2-烯丙基-1-羟基蒽-9,10-二酮;R162,谷氨酸脱氢酶(GDH1)抑制剂
- CBNumber:
- CB83334050
- 分子式:
- C17H12O3
- 分子量:
- 264.28
- MOL File:
- 64302-87-0.mol
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R162化学性质
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熔点:
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120-120.5 °C(Solv: acetone (67-64-1))
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沸点:
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459.0±34.0 °C(Predicted)
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密度:
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1.308±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO (up to 10 mg/ml or in Ethanol (up to 5 mg/ml)
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形态:
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solid
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酸度系数(pKa):
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7.43±0.20(Predicted)
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颜色:
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Orange
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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R162性质、用途与生产工艺
R162 是一种有效的谷氨酸脱氢酶 (GDH1/GLUD1) 抑制剂，具有抗癌的作用。
Inhibition of GDH1 activity by R162 treatment results in decreased intracellular fumarate levels, attenuated GPx activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells, which can be significantly rescued by methyl-α-KG treatment as well as by antioxidant NAC. R162 inhibits cell proliferation and tumor growth potential of human cancer cells.
R162 (30 mg/kg/day, i.p.) does not result in a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties in xenograft tumor mouse models. R162 (20 mg/kg/day) results in significantly decreased tumor growth and masses in mice compared with control mice and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice.
R162
上下游产品信息
上游原料
下游产品
64302-87-0, R162 相关搜索:
- 药靶配体
- R162,谷氨酸脱氢酶(GDH1)抑制剂
- 2-烯丙基-1-羟基蒽-9,10-二酮
- 化合物R162
- 64302-87-0
- R162,inhibit,R-162,Inhibitor,R 162
- 9,10-Anthracenedione, 1-hydroxy-2-(2-propen-1-yl)-
- 2-Allyl-1-hydroxy-9,10-anthraquinone
- R162, >98%
- R162;R-162;R 162