4-乙氧基-N-(5-硝基噻唑-2-基)苯甲酰胺
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- CAS号:
- 312608-54-1
- 英文名:
- Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl)
- 英文别名:
- ChemBridge5655896;4-ethoxy-N-(5-nitrothiazol-2-yl)benzamide;Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl);4-ethoxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide;MID-1,inhibit,Inhibitor,MG53,ubiquitination,Insulin Receptor,insulin,association,glucose,MID1,IRS-1,MID 1,degradation
- 中文名:
- 4-乙氧基-N-(5-硝基噻唑-2-基)苯甲酰胺
- 中文别名:
- 化合物MID-1;4-乙氧基-N-(5-硝基噻唑-2-基)苯甲酰胺
- CBNumber:
- CB83352890
- 分子式:
- C12H11N3O4S
- 分子量:
- 293.3
- MOL File:
- 312608-54-1.mol
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4-乙氧基-N-(5-硝基噻唑-2-基)苯甲酰胺化学性质
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密度:
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1.442±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 31.25 mg/mL (106.55 mM)
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酸度系数(pKa):
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6.62±0.50(Predicted)
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4-乙氧基-N-(5-硝基噻唑-2-基)苯甲酰胺性质、用途与生产工艺
MID-1 是一种 MG53-IRS-1 (Mitsugumin 53-胰岛素受体底物 1) 相互作用的抑制剂。 MID-1 破坏了 MG53 与 IRS-1 的分子缔合，并消除了 MG53 诱导的 IRS-1 泛素化和骨骼肌降解，从而导致 IRS-1 表达水平升高，胰岛素信号传导和葡萄糖摄取增加。
MID-1 (5 μM; 24 h) increases the IRS-1 expression level in skeletal muscle by disrupting the MG53-IRS-1 interaction.
MID-1 (10 μM; 12 h) reduces the luciferase activity in HEK 293 cell line expressing NLUC-IRS-1 and CLUC-C14A.
MID-1 (1-20 μM; 12 h) disrupts the MG53-IRS-1 interaction but not MG53-FAK interaction in HEK 293 cells.
MID-1 (0.1-10 μM; 4-24 h) abolishes MG53-induced IRS-1 ubiquitination and degradation in HEK 293 cells.
MID-1 (5-10 μM; 24 h) increases insulin signaling and insulin-elicited glucose uptake in C2C12 myotubes.
MID-1 (5-10 μM; 24 h) enhances skeletal myogenesis.
Western Blot Analysis
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Cell Line:
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C2C12 myotubes
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Concentration:
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5 μM
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Incubation Time:
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24 h
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Result:
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Increased the IRS-1 protein level.
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MID-1 does not have good pharmacokinetics in vivo.
4-乙氧基-N-(5-硝基噻唑-2-基)苯甲酰胺
上下游产品信息
上游原料
下游产品
4-乙氧基-N-(5-硝基噻唑-2-基)苯甲酰胺
生产厂家
312608-54-1, 4-乙氧基-N-(5-硝基噻唑-2-基)苯甲酰胺 相关搜索:
- 化合物MID-1
- 4-乙氧基-N-(5-硝基噻唑-2-基)苯甲酰胺
- 312608-54-1
- 4-ethoxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
- MID-1,inhibit,Inhibitor,MG53,ubiquitination,Insulin Receptor,insulin,association,glucose,MID1,IRS-1,MID 1,degradation
- ChemBridge5655896
- 4-ethoxy-N-(5-nitrothiazol-2-yl)benzamide
- Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl)