CS-2628
|
|
- CAS号:
- 187034-31-7
- 英文名:
- TAPI-2
- 英文别名:
- TAPI-2;CS-2628;TAPI2;TAPI 2;TNF Protease Inhibitor 2;TNF-ALPHA PROTEASE INHIBITOR-2;TAPI-2 (TNF Protease Inhibitor 2);HONHCOCH2CH(CH2-CH(CH3)2)CO-T-LEU-ALA-NHCH2CH2NH2;N-(R)-(2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL-L-T-BUTYL-GLYCYL-L-ALANINE 2-AMINOETHYL AMIDE;N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-T-BUTYL-ALANYL-L-ALANINE, 2-AMINOETHYL AMIDE;N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
- 中文名:
- CS-2628
- 中文别名:
- 化合物TAPI-2;MMP/TACE和ADAM抑制剂(TAPI-2)
- CBNumber:
- CB8374178
- 分子式:
- C19H37N5O5
- 分子量:
- 415.53
- MOL File:
- Mol file
|
|
|
CS-2628化学性质
-
密度:
-
1.127±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Ethanol: 5 mg/ml; Water: 8 mg/ml
-
|
-
形态:
-
Solid
-
|
-
酸度系数(pKa):
-
9.17±0.20(Predicted)
-
|
-
敏感性:
-
Light Sensitive & Hygroscopic
-
|
CS-2628性质、用途与生产工艺
TAPI-2 (TNF Protease Inhibitor 2) 是基质金属蛋白酶 (MMP),肿瘤坏死因子α 转换酶 (TACE) 和解联蛋白和金属蛋白酶 (ADAM) 的广谱抑制剂, 对 MMP 的IC50 值为 20 μM。TAPI-2 阻止传染性 SARS-CoV 进入。
The hydroxamate-based metalloprotease inhibitor TAPI-2 bounds to hmeprin with inhibition constants IC
50
20±10 μM for hmeprin
β
subunit and 1.5±0.27 nM for hmeprin
α
subunit. Generally, hmeprin
α
is inhibited more strongly than the β subunit. Without affecting ADAM17 expression, TAPI-2 dramatically decreases the protein levels of NICD and its downstream target HES-1 in both HCP-1 and HT29 cells. Moreover, treating cells with TAPI-2 significantly decreases the CSC phenotype by -50% in both CRC cell lines. The dose-dependent effects of TAPI-2 on the sphere formation and protein levels of NICD and HES-1 confirm that the concentration used (20 μM) is within the effective dose range of TAPI-2 (5-40 μM).
CS-2628
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-100211 | CS-2628 TAPI-2 | 187034-31-7 | 1mg | 1700元 |
2024/04/30 | HY-100211 | CS-2628 TAPI-2 | 187034-31-7 | 5mg | 6000元 |
187034-31-7, CS-2628 相关搜索:
- A hydroxamate-based inhibitor of MMPs and TACE.
- 细胞生物学试剂
- C19H37N5O5
- 化合物TAPI-2
- MMP/TACE和ADAM抑制剂(TAPI-2)
- 187034-31-7
- TAPI-2 (TNF Protease Inhibitor 2)
- L-Alaninamide, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-
- TNF Protease Inhibitor 2
- TAPI2;TAPI 2
- CS-2628
- N-[2-[2-(HydroxyaMino)-2-oxoethyl]-4-Methyl-1-oxopentyl]-3-Methyl-L-valyl-N-(2-aMinoethyl)-L-alaninaMide Acetic Acid
- N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
- HONHCOCH2CH(CH2-CH(CH3)2)CO-T-LEU-ALA-NHCH2CH2NH2
- TNF-ALPHA PROTEASE INHIBITOR-2
- N-(R)-(2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL-L-T-BUTYL-GLYCYL-L-ALANINE 2-AMINOETHYL AMIDE
- N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-T-BUTYL-ALANYL-L-ALANINE, 2-AMINOETHYL AMIDE
- TAPI-2