ML-00253764 HYDROCHLORIDE
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- CAS号:
- 1706524-94-8
- 英文名:
- ML-00253764 (hydrochloride)
- 英文别名:
- ML00253764 hydrochloride,ML 00253764 hydrochloride;2-[2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride
- 中文名:
- ML-00253764 HYDROCHLORIDE
- 中文别名:
- 化合物 T12072
- CBNumber:
- CB84667027
- 分子式:
- C18H19BrClFN2O
- 分子量:
- 413.72
- MOL File:
- 1706524-94-8.mol
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ML-00253764 HYDROCHLORIDE化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 30mg/mL; DMF:PBS (pH 7.2) (1:20): 0.5mg/mL; DMSO: 25mg/mL; Ethanol: 1mg/mL
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形态:
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A crystalline solid
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ML-00253764 HYDROCHLORIDE性质、用途与生产工艺
ML-00253764 是一种非肽类黑皮质素受体4 (MC4R) 拮抗剂，其 Ki 和 IC50 值分别为 0.16 µM 和 0.103 µM。脑渗透剂。
ML-00253764 displaces NDP-α-MSH binding with a mean IC
50
of 0.32 μM, 0.81 μM and 2.12 μM for hMC4-R, hMC3-R and hMC5-R, respectively.
ML-00253764 (100 µM) decreases cAMP production induced by [NLE4,D-Phe7]-α-melanocyte stimulating hormone ([NDP]-α-MSH) by 20% in MC4R-expressing HEK293 cell membranes, but has no effect on cAMP levels in MC3R- or MC5R-expressing membranes.
ML-00253764 (subcutaneous injection; 3, 10, or 30 mg/kg; once daily) shows protection against tumor-induced body weight loss upon chronic, peripheral dosing in CT-26 tumor bearing BALB/c mice.ML-00253764 dissolves in polyethylene glycol 200/saline (1:10) in a volume of 10 ml/kg.
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Animal Model:
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CT-26 tumor bearing BALB/c mice
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Dosage:
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3, 10, or 30 mg/kg
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Administration:
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Subcutaneous injection; 3, 10, or 30 mg/kg; once daily
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Result:
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Reduced tumor-induced weight loss in a mouse model.
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ML-00253764 HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
ML-00253764 HYDROCHLORIDE
生产厂家
1706524-94-8, ML-00253764 HYDROCHLORIDE 相关搜索:
- 化合物 T12072
- 1706524-94-8
- ML00253764 hydrochloride,ML 00253764 hydrochloride
- 2-[2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride