(R)-(-)-α-Methylhistamine dihydrobromide

生物活性靶点体外研究体内研究

CAS号:: 868698-49-1

英文名:: (R)-(-)-α-Methylhistamine dihydrobromide

英文别名:: (R)-(-)-α-Methylhistamine dihydrobromide;(αR)?-α-?Methyl-1H-?imidazole-?5-?ethanamine Hydrobromide;(R)()αMethylhistamine dihydrobromide,(R) ( ) α Methylhistamine dihydrobromide

中文名:: (R)-(-)-α-Methylhistamine dihydrobromide

中文别名:: 化合物 T12630;(R)()-Α-甲基组胺二盐酸盐

CBNumber:: CB84806424

分子式:: C6H12BrN3

分子量:: 206.09

MOL File:: 868698-49-1.mol

化学性质安全信息用途供应商 14

(R)-(-)-α-Methylhistamine dihydrobromide化学性质

储存条件:: Desiccate at RT

形态:: White solid.

水溶解性:: Soluble to 100 mM in water

安全信息

(R)-(-)-α-Methylhistamine dihydrobromide性质、用途与生产工艺

生物活性

(R)-(-)-α-Methylhistamine dihydrobromide 是一种有效的选择性 H3 组胺受体激动剂，Kd 值为 50.3 nM。(R)-(-)-α-Methylhistamine dihydrobromide 可透过血脑屏障，并可增强记忆力，减轻大鼠的记忆力障碍。

(R)-(-)-α-Methylhistamine dihydrobromide is an H3-agonist that is > 10 times as potent as histamine (HA). Its selectivity toward H3-receptors is > 1,000 times as high as that of HA. (R)-(-)-α-Methylhistamine dihydrobromide has only weak affinities for H1 and H2 receptor with a pKi=4.8 and < 3.5, repectively. (R)-(-)-α-Methylhistamine dihydrobromide displays >200-fold selectivity over H4 receptors.

体内研究

Pretreatment with (R)-(-)-α-Methylhistamine dihydrobromide (RAMH; 10 mg/kg; i.p.; 60 min before training) reverses propofol‐induced (25 mg/kg; i.p.; 30 min before training) memory retention.
(R)-alpha-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level.

Animal Model:	Male Sprague‐Dawley rats (10-12 week)
Dosage:	10 mg/kg
Administration:	IP; 60 min before training
Result:	Reversed propofol‐induced memory retention.

(R)-(-)-α-Methylhistamine dihydrobromide 上下游产品信息

上游原料

下游产品

(R)-(-)-α-Methylhistamine dihydrobromide 生产厂家

全球有 14家供应商 (R)-(-)-α-Methylhistamine dihydrobromide国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	美国	14059	65
上海一飞生物科技有限公司	021-65675885 18964387627	info@efebio.com	中国	9709	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
MedBio脉铂医药	021-69568360 18916172912	order@med-bio.cn	中国	8141	58
成都超九八生物科技有限公司	13348960310 13348960310	3003867561@qq.com	中国	9946	58
天津普西唐生物医药科技有限公司	010-60605840	psaitong@jm-bio.com	中国	29778	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24018	58
沈阳中申泽康生物医学技术研究有限公司	024-024-88590548 18341751992	757984502@qq.com	中国	888	58
长沙福臻生物科技有限公司	0731-18670069958 18670069958	184792226@qq.com	中国	3060	58
Aladdin Scientific Corporation	+1-833-552-7181	sales@aladdinsci.com	美国	52927	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	中国	892	58
ApexBio技术		sales@apexbt.com	美国	6254	58

868698-49-1, (R)-(-)-α-Methylhistamine dihydrobromide 相关搜索:

盐酸氮卓斯汀阿司咪唑 1-（4-氰基-4-（4-氟苯基）环己基）-3-甲基-4-苯基哌啶-4-羧酸一盐酸盐富马酸酮替芬 CS-336

化合物 T12630
(R)()-Α-甲基组胺二盐酸盐
868698-49-1
(R)()αMethylhistamine dihydrobromide,(R) ( ) α Methylhistamine dihydrobromide
(αR)?-α-?Methyl-1H-?imidazole-?5-?ethanamine Hydrobromide
(R)-(-)-α-Methylhistamine dihydrobromide