TM-25659
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- CAS号:
- 260553-97-7
- 英文名:
- TM-25659
- 英文别名:
- TM-25659;TM 25659,TM25659;3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-5-methyl-6-(pyridin-3-yl)-3H-imidazo[4,5-b]pyridine;3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-5-methyl-6-(pyridin-3-yl)-3H-imidazo[4,5-b]pyridine;3H-Imidazo[4,5-b]pyridine, 2-butyl-5-methyl-6-(3-pyridinyl)-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
- 中文名:
- TM-25659
- 中文别名:
- 化合物 T13169;化合物TM-25659;3-((2'-(2H-四唑-5-基)-[1,1'-联苯]-4-基)甲基)-2-丁基-5-甲基-6-(吡啶-3-基)-3H-咪唑并[4,5-B]吡啶;3-((2'-(2H-四唑-5-基)-[1,1'-联苯]-4-基)甲基)-2-丁基-5-甲基-6-(吡啶-3-基)-3H-咪唑并[4,5-B]吡啶
- CBNumber:
- CB84845065
- 分子式:
- C30H28N8
- 分子量:
- 500.6
- MOL File:
- 260553-97-7.mol
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TM-25659化学性质
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沸点:
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768.0±70.0 °C(Predicted)
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密度:
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1.29±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 135 mg/mL (269.68 mM);Water : < 0.1 mg/mL (insoluble)
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酸度系数(pKa):
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4.15±0.10(Predicted)
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TM-25659性质、用途与生产工艺
TM-25659是 具有PDZ结合基序的转录共激活子 (TAZ) 的调制剂。抗骨质疏松和抗肥胖活性。
TM-25659 (2, 10, 20, 100 μM) enhances nuclear TAZ localization in a dose-dependent manner and attenuates PPARγ-mediated adipocyte differentiation by facilitating PPARγ suppression activity of TAZ.
TM-25659 (2, 10, 50 μM) enhances osteogenic gene expression and thereby increases osteoblast differentiation.
Cell Proliferation Assay
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Cell Line:
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3T3-L1 cells
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Concentration:
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2, 10, 20, 100 μM
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Incubation Time:
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6 days
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Result:
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Acted as a suppressor of PPARγ-dependent adipocyte differentiation
[1]
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TM-25659 (50 mg/kg, i.p., every other day for 2 weeks) suppresses bone loss
in vivo
and decreases weight gain in an obesity model.
TM-25659 has a favourable pharmacokinetic profile in rats. The plasma concentration of TM-25659 declines with an approximate t
1/2
of 7 or 10 h following i.v or p.o. administration respectively. The systemic clearance (CL) is 0.21 L×h
-1
×kg
-1
and the volume of distribution at steady-state (1.91 L×h
-1
×kg
-1
) is larger than the volume of total body fluids.
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Animal Model:
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C57BL6 mice (4- to 6-week-old )
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Dosage:
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50 mg/kg
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Administration:
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I.p., every other day for 2 weeks
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Result:
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Attenuated weight gain in these obese mice
[1]
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Animal Model:
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Adult male Sprague-Dawley rats
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Dosage:
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10 mg/kg
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Administration:
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I.v. (2, 10 and 30 min), oral (15 and 30 min, and 1, 2, 4 and 8 h)
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Result:
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Oral administration for 4 weeks moderately but significantly attenuated weight gain and partly restored BMD in the OVX rats
[1]
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TM-25659
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-112920 | TM-25659
TM-25659 | 260553-97-7 | 5mg | 1600元 |
| 2024/04/30 | HY-112920 | TM-25659
TM-25659 | 260553-97-7 | 10mM * 1mLin DMSO | 1760元 |
260553-97-7, TM-25659 相关搜索:
- C30H28N8
- 3-((2'-(2H-四唑-5-基)-[1,1'-联苯]-4-基)甲基)-2-丁基-5-甲基-6-(吡啶-3-基)-3H-咪唑并[4,5-B]吡啶
- 化合物TM-25659
- 化合物 T13169
- 3-((2'-(2H-四唑-5-基)-[1,1'-联苯]-4-基)甲基)-2-丁基-5-甲基-6-(吡啶-3-基)-3H-咪唑并[4,5-B]吡啶
- 260553-97-7
- 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-5-methyl-6-(pyridin-3-yl)-3H-imidazo[4,5-b]pyridine
- 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-5-methyl-6-(pyridin-3-yl)-3H-imidazo[4,5-b]pyridine
- TM 25659,TM25659
- 3H-Imidazo[4,5-b]pyridine, 2-butyl-5-methyl-6-(3-pyridinyl)-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
- TM-25659