ALPHA-玉米赤霉烯醇
|
|
|
- CAS号:
- 36455-72-8
- 英文名:
- ALPHA-ZEARALENOL
- 英文别名:
- ZEARALENOL;Α-ZEARALENOL;A-ZEARALENOL;(3S,7R,11E)-;α-Zearalenol;alfa-Zearalenol;ALPHA-ZEARALENOL;trans-α-Zearalenol;Zearalenol, alpha-;α-Zearalenol solution
- 中文名:
- ALPHA-玉米赤霉烯醇
- 中文别名:
- 玉米赤霉烯醇Α;Α-玉米赤霉烯醇;A-玉米赤霉烯醇;化合物 T13542;ALPHA-玉米赤霉烯醇;Α-玉米赤霉烯醇 标准品;ALFA-ZEARALENOL;Α-玉米赤霉烯醇溶液,100PPM;Α-玉米赤霉烯醇溶液,1000PPM;乙腈中Α-玉米赤霉烯醇溶液,100ΜG/ML
- CBNumber:
- CB8491950
- 分子式:
- C18H24O5
- 分子量:
- 320.38
- MOL File:
- 36455-72-8.mol
|
|
|
ALPHA-玉米赤霉烯醇化学性质
-
熔点:
-
158-161°C
-
|
-
沸点:
-
599.0±50.0 °C(Predicted)
-
|
-
密度:
-
1.174±0.06 g/cm3(Predicted)
-
|
-
闪点:
-
2℃
-
|
-
储存条件:
-
-20°C
-
|
-
溶解度:
-
≤20mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
-
|
-
形态:
-
crystalline solid
-
|
-
酸度系数(pKa):
-
7.61±0.60(Predicted)
-
|
-
稳定性:
-
Hygroscopic
-
|
ALPHA-玉米赤霉烯醇性质、用途与生产工艺
α-Zearalenol 是一种对雌激素受体 (ER) 具有高亲和力的霉菌毒素,
α-Zearalenol 是 zearalenone (ZEN) 的衍生物，由于其异种雌激素效应可引起动物的生殖障碍。
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells with an IC
50
of 12.5 μM.
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells.
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) increases MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells.
α-Zearalenol (α-zol) (1-10 μM; 24 hours) reduces the expression of TNF-α, α-ZOL combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergic for IL-8 at high toxin concentrations.
Cell Proliferation Assay
|
Cell Line:
|
MFC-7 cells
|
|
Concentration:
|
6.25 µM-25 µM
|
|
Incubation Time:
|
24 hours
|
|
Result:
|
Observed the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells.
|
Cell Viability Assay
|
Cell Line:
|
Breast cancer cell lines: MCF-7 and MDA-MB231
|
|
Concentration:
|
0.001 μM, 0.1 μM and 10 μM
|
|
Incubation Time:
|
24 hours, 48 hours, 72 hours
|
|
Result:
|
Modified the cell growth in two breast cancer cell lines.
|
Cell Cycle Analysis
|
Cell Line:
|
MCF7 cells, MDA-MB231 cells
|
|
Concentration:
|
0.001 μM, 0.1 μM and 10 μM
|
|
Incubation Time:
|
72 hours
|
|
Result:
|
Observed an increase of cells in cell cycle in MCF7 cells.
|
RT-PCR
|
Cell Line:
|
HepG2 cells
|
|
Concentration:
|
1 μM, 5 μM, 10 μM
|
|
Incubation Time:
|
72 hours
|
|
Result:
|
Induced a decrease of the expression of TNF-α, IL-1β and IL-8, that was in most cases statistically significant for the higher doses.
|
ALPHA-玉米赤霉烯醇
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-N6710 | ALPHA-玉米赤霉烯醇
α-Zearalenol | 36455-72-8 | 5mg | 2800元 |
| 2024/04/30 | HY-N6710 | α-Zearalenol | | 10 mM * 1 mLin DMSO | 3080元 |
36455-72-8, ALPHA-玉米赤霉烯醇 相关搜索:
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- Heterocycles
- Chiral Reagents
- 对照品
- 化工原料
- 细胞生物学
- 霉菌毒素类
- 微生物代谢物
- A-玉米赤霉烯醇
- 化合物 T13542
- Α-玉米赤霉烯醇
- 乙腈中Α-玉米赤霉烯醇溶液,100ΜG/ML
- ALFA-ZEARALENOL
- Α-玉米赤霉烯醇 标准品
- 2,4-二羟基- 6-(6Α,10-二羟基反式-)苯甲酸Μ-内酯
- ALPHA-玉米赤霉烯醇
- ALPHA-2,4二羟基- 6 - [10 -二羟基- 1 - 十一碳烯基]苯甲酸酯
- Α-玉米赤霉烯醇溶液,100PPM
- Α-玉米赤霉烯醇溶液,1000PPM
- 玉米赤霉烯醇Α
- 36455-72-8
- α-Zearalenol
- 2,4-Dihydroxy-6-(6Alpha,10-dihydroxy-trans-1-undecenyl)benzoicacidμ-lactone
- α-Zearalenol Solution in Acetonitrile, 100μg/mL
- alpha-Zearalenol solution
- alfa-Zearalenol
- alpha Zearalenol from Giberella zeae
- (2E,7R,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,15,17-tetraen-13-one
- 2,4-DIHYDROXY-6-[6ALPHA,10-DIHYDROXY-TRANS-1-UNDECENYL]BENZOIC ACID MICRO-LACTONE
- (3S,7R,11E)-
- 1H-2-Benzoxacyclotetradecin-1-one, 3,4,5,6,7,8,9,10-octahydro-7,14,16-trihydroxy-3-methyl-, (3S,7R,11E)-
- 1H-2-Benzoxacyclotetradecin-1-one, 3,4,5,6,7,8,9,10-octahydro-7,14,16-trihydroxy-3-methyl-, (3S-(3R*,7S*,11E))-
- trans-α-Zearalenol
- (3S,7R,11E)-3,4,5,6,7,8,9,10-Octahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one
- A-ZEARALENOL
- 2,4-Dihydroxy-6-(6α,10-dihydroxy-trans-1-undecenyl)benzoic acid μ-lactone
- α-Zearalenol,2,4-Dihydroxy-6-(6α,10-dihydroxy-trans-1-undecenyl)benzoic acid μ-lactone
- ALPHA-ZEARALENOL
- ZEARALENOL
- Α-ZEARALENOL
- α-Zearalenol solution
- 2,4-Dihydroxy-6-(6α,10-dihydroxy-trans-1-undecenyl)benzoic acid μ-lactone solution
- Zearalenol, alpha-