NIGRANOIC ACID
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- CAS号:
- 39111-07-4
- 英文名:
- NIGRANOIC ACID
- 英文别名:
- NIGRANOIC ACID;(3S,3aR,4aS,6aR,7R,9aS,9bS)-7-[(1R,4Z)-5-Carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-1H-cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid;1H-Cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid, 7-[(1R,4Z)-5-carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-, (3S,3aR,4aS,6aR,7R,9aS,9bS)-
- 中文名:
- NIGRANOIC ACID
- 中文别名:
- 黑五味子酸
- CBNumber:
- CB8693381
- 分子式:
- C30H46O4
- 分子量:
- 470.69
- MOL File:
- Mol file
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NIGRANOIC ACID化学性质
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熔点:
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128-130 °C
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沸点:
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603.0±28.0 °C(Predicted)
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密度:
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1.10±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
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形态:
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Powder
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酸度系数(pKa):
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4.78±0.10(Predicted)
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NIGRANOIC ACID性质、用途与生产工艺
Nigranoic acid 是五味子中分离得到的一种三萜类化合物。Nigranoic acid 能抑制 HIV-1 逆转录酶。在脑缺血再灌注动物模型中,Nigranoic acid 通过 PARP/AIF 信号通路保护大脑。
HIV-1 reverse transcriptase
Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation.
Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
Animal Model:
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Sprague–Dawley rats (200-300 g), ischemia–reperfusion model
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Dosage:
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1 mg/kg
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Administration:
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Intragastric; 6 hours and 2 hours before brain ischemia
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Result:
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Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
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NIGRANOIC ACID
上下游产品信息
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-122935 | Nigranoic acid | | 1 mg | 2600元 |
2024/04/30 | HY-122935 | NIGRANOIC ACID Nigranoic acid | 39111-07-4 | 5mg | 6500元 |
39111-07-4, NIGRANOIC ACID 相关搜索:
- 中药对照品
- 黑五味子酸
- 39111-07-4
- 1H-Cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid, 7-[(1R,4Z)-5-carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-, (3S,3aR,4aS,6aR,7R,9aS,9bS)-
- (3S,3aR,4aS,6aR,7R,9aS,9bS)-7-[(1R,4Z)-5-Carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-1H-cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid
- NIGRANOIC ACID