CBR-5884
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- CAS号:
- 681159-27-3
- 英文名:
- CBR-5884
- 英文别名:
- CBR-5884;CBR 5884;CBR5884;CBR 5884,inhibit,CBR-5884,Inhibitor,CBR5884;ethyl 4-(cyanosulfanyl)-5-(furan-2-amido)-3-methylthiophene-2-carboxylate;Ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate;Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate;2-Thiophenecarboxylic acid, 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-, ethyl ester
- 中文名:
- CBR-5884
- 中文别名:
- 化合物CBR-5884
- CBNumber:
- CB93128968
- 分子式:
- C14H12N2O4S2
- 分子量:
- 336.39
- MOL File:
- 681159-27-3.mol
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CBR-5884化学性质
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沸点:
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378.1±42.0 °C(Predicted)
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密度:
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1.43±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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Soluble in DMSO (up to 50 mg/ml) or in DMF (up to 50 mg/ml).
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酸度系数(pKa):
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11.25±0.70(Predicted)
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形态:
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paste
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颜色:
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white to beige
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 2 months.
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CBR-5884性质、用途与生产工艺
CBR-5884 是一种 phosphoglycerate dehydrogenase (PHGDH) 的选择性抑制剂，对应的IC50值为33 μM。CBR-5884 可抑制癌细胞中从头合成丝氨酸，并且对具有高丝氨酸生物合成活性的癌细胞具有选择性毒性。
| Target | Value |
PHGDH
(Cell-free assay)
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33 μM
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CBR-5884
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100012 | CBR-5884 | | 1 mg | 250元 |
| 2024/04/30 | HY-100012 | CBR-5884
CBR-5884 | 681159-27-3 | 5mg | 550元 |
681159-27-3, CBR-5884 相关搜索:
- 药靶配体
- 化合物CBR-5884
- 681159-27-3
- Ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate
- CBR 5884,inhibit,CBR-5884,Inhibitor,CBR5884
- 2-Thiophenecarboxylic acid, 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-, ethyl ester
- ethyl 4-(cyanosulfanyl)-5-(furan-2-amido)-3-methylthiophene-2-carboxylate
- CBR 5884;CBR5884
- Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate
- CBR-5884