133804-44-1
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- CAS号:
- 133804-44-1
- 英文名:
- 5-METHYL-2-(1-PIPERAZINYL)BENZENESULFONIC ACID MONOHYDRATE
- 英文别名:
- Caldaret;Benzenesulfonic acid, 5-methyl-2-(1-piperazinyl)-;5-METHYL-2-(1-PIPERAZINYL)BENZENESULFONIC ACID MONOHYDRATE
- 中文名:
- 133804-44-1
- 中文别名:
- 化合物 T14857
- CBNumber:
- CB9428157
- 分子式:
- C11H16N2O3S
- 分子量:
- 256.32
- MOL File:
- 133804-44-1.mol
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133804-44-1化学性质
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密度:
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1.302±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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-1.76±0.42(Predicted)
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133804-44-1性质、用途与生产工艺
Caldaret 是一种细胞内 Ca2+ 调节剂,通过反向模式抑制 Na+/Ca2+ 交换作用。
Caldaret (MCC-135) is demonstrated to restore Ca
2+
-ATPase activity of the sarcoplasmic reticulum (SR) isolated from the myocardium acutely exposed to ischemia and reperfusion in vitro.
Caldaret, an intracellular Ca
2+
handling modulator, limits infarct size of reperfused canine heart. The cardioprotective effect of Caldaret, a novel intracellular Ca
2+
handling modulator that acts through reverse-mode Na
+
/Ca
2+
exchanger inhibition and potential sarcoplasmic reticulum (SR) Ca
2+
uptake enhancement, against reperfusion injury is investigated. Intravenously infused Caldaret (3 or 30 microg/kg per hour) for 30 min at left circumflex (LCX)-reperfusion markedly reduces infarct size (by 51.3% or 71.9%, respectively). The amelioration of intracellular Ca
2+
handling dysfunction achieved by Caldaret leads to cardioprotective effects against reperfusion injury following prolonged ischemia. Caldaret (MCC-135) is a new potent compound with beneficial effects in heart failure. In diabetic rats, Caldaret decreases TR80 significantly without significant effect on developed tension (DT). Caldaret has minimal effects on SR Ca
2+
uptake in normal rats, that is observed as increased SR Ca
2+
uptake at uptake time of 20 and 30 s at the highest concentration of 10 μM. In diabetic rats, Caldaret increases SR Ca
2+
uptake all over the range of uptake time. Both initial rate of SR Ca
2+
uptake and the amount of Ca
2+
accumulated in the SR with longer uptake time are increased by Caldaret.
133804-44-1
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-100298 | 133804-44-1 Caldaret | 133804-44-1 | 5 mg | 6140元 |
2024/04/30 | HY-100298 | 133804-44-1 Caldaret | 133804-44-1 | 10 mg | 8600元 |
133804-44-1, 133804-44-1 相关搜索:
- 化合物 T14857
- 133804-44-1
- Benzenesulfonic acid, 5-methyl-2-(1-piperazinyl)-
- Caldaret
- 5-METHYL-2-(1-PIPERAZINYL)BENZENESULFONIC ACID MONOHYDRATE