SC-43
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- CAS号:
- 1400989-25-4
- 英文名:
- SC-43
- 英文别名:
- SC-43;1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(4-cyanophenoxy)phenyl)urea;Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[3-(4-cyanophenoxy)phenyl]-;antiproliferative,Inhibitor,SC-43,SHP-1,PTPN6,Phosphatase,Apoptosis,caspase-3,SC 43,anti-fibrotic,p-STAT3,anticancer,orally,SC43,PARP,STAT,inhibit
- 中文名:
- SC-43
- 中文别名:
- 化合物SC-43;1-(4-氯-3-(三氟甲基)苯基)-3-(3-(4-氰基苯氧基)苯基)脲
- CBNumber:
- CB94801426
- 分子式:
- C21H13ClF3N3O2
- 分子量:
- 431.8
- MOL File:
- 1400989-25-4.mol
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SC-43化学性质
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沸点:
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462.0±45.0 °C(Predicted)
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密度:
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1.46±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (578.97 mM)
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形态:
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A solid
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酸度系数(pKa):
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12.92±0.70(Predicted)
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SC-43性质、用途与生产工艺
SC-43 是索拉非尼sorafenib的衍生物，是一种 Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) 的激动剂，可减少肝纤维化。SC-43 可减少 p-STAT3 并诱导凋亡，具有抗肿瘤的活性。
| Target | Value |
SHP-1
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STAT3
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SC-43 (0-10 μM; 24-72 hours; HuCCT-1, KKU-100, and CGCCA cells) treatment reveals the anti-proliferative effects in cholangiocarcinoma (CCA) cell lines in a dose-dependent manner after treating 24, 48 and 72 hours respectively.
SC-43 (0-10 μM; 24 hours; HuCCT-1, KKU-100, and CGCCA cells) treatment shows increased sub-G1 cells and G2-M arrest, indicating SC-43 induced differential apoptotic effects in these cell lines.
SC-43 (0-10 μM; 24 hours; HuCCT-1, KKU-100, and CGCCA cells) treatment demonstrates significant increase in cleaved caspase-3 and PARP level.
SC-43 activates SH2 domain-containing phosphatase 1 (SHP-1) activity, leading to p-STAT3 and downstream cyclin B1 and Cdc2 downregulation. SC-43 augments SHP-1 activity by direct binding to N-SH2 and relief of its autoinhibition.
Cell Viability Assay
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Cell Line:
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HuCCT-1, KKU-100, and CGCCA cells
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Concentration:
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0 μM, 0.25 μM, 0.5 μM, 0.75 μM, 1 μM, 2.5 μM, 5 μM, 10 μM
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Incubation Time:
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24 hours, 48 hours, 72 hours
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Result:
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Revealed the anti-proliferative effects in CCA cell lines in a dose-dependent manner after treating 24, 48 and 72 hours respectively.
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Cell Cycle Analysis
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Cell Line:
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HuCCT-1, KKU-100, and CGCCA cells
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Concentration:
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0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM
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Incubation Time:
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24 hours
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Result:
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Showed increased sub-G1 cells and G2-M arrest.
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Western Blot Analysis
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Cell Line:
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HuCCT-1, KKU-100, and CGCCA cells
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Concentration:
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0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM
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Incubation Time:
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24 hours
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Result:
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Demonstrated significant increase in cleaved caspase-3 and PARP level.
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SC-43 (10-30 mg/kg; oral gavage; daily; for 23 days; male NCr athymic nude mice) treatment exhibits xenograft tumor growth inhibition, p-STAT3 reduction and SHP-1 activity elevation.
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Animal Model:
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Male NCr athymic nude mice (5-7 weeks of age) injected with HuCCT-1 cells
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Dosage:
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10 mg/kg or 30 mg/kg
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Administration:
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Oral gavage; daily; for 23 days
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Result:
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Exhibited xenograft tumor growth inhibition, p-STAT3 reduction and SHP-1 activity elevation.
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SC-43
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-136657 | SC-43 | | 1 mg | 952元 |
| 2024/04/30 | HY-136657 | SC-43
SC-43 | 1400989-25-4 | 5mg | 2500元 |
1400989-25-4, SC-43 相关搜索:
- 药靶配体
- 1-(4-氯-3-(三氟甲基)苯基)-3-(3-(4-氰基苯氧基)苯基)脲
- 化合物SC-43
- 1400989-25-4
- antiproliferative,Inhibitor,SC-43,SHP-1,PTPN6,Phosphatase,Apoptosis,caspase-3,SC 43,anti-fibrotic,p-STAT3,anticancer,orally,SC43,PARP,STAT,inhibit
- Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[3-(4-cyanophenoxy)phenyl]-
- SC-43
- 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(4-cyanophenoxy)phenyl)urea