2-(trans-4-Aminocyclohexyl)propan-2-ol
- CAS No.
- 899806-45-2
- Chemical Name:
- 2-(trans-4-Aminocyclohexyl)propan-2-ol
- Synonyms
- 2-((1r,4r)-4-aMinocyclohexyl)propan-2-ol;SW-25;SWF-25;2-(trans-4-Aminocyclohexyl);2-(trans-4-AMino-cyclohex...;2-(4-aminocyclohexyl)-2-propanol;2-(4-aminocyclohexyl)propan-2-ol;2-(trans-4-AMino-cyclohexyl)-propan-2-ol;TRANS-2-(4-AMINOCYCLOHEXYL)-2-HYDROXYPROPANE;Cyclohexanemethanol,4-amino-a,a-dimethyl-, trans-
- CBNumber:
- CB01519349
- Molecular Formula:
- C9H19NO
- Molecular Weight:
- 157.26
- MDL Number:
- MFCD11053512
- MOL File:
- 899806-45-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302+H312+H332-H314 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| RIDADR | UN3259 |
2-(trans-4-Aminocyclohexyl)propan-2-ol price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| SynQuest Laboratories | 4H56-1-QQ | 2-(trans-4-Aminocyclohexyl)propan-2-ol | 899806-45-2 | 250mg | $149 | 2021-12-16 | Buy |
| AK Scientific | 4947AC | 2-(trans-4-Aminocyclohexyl)propan-2-ol | 899806-45-2 | 1g | $291 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H56-1-QQ | 2-(trans-4-Aminocyclohexyl)propan-2-ol | 899806-45-2 | 1g | $395 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0158356 | TRANS-2-(4-AMINOCYCLOHEXYL)-2-HYDROXYPROPANE 95.00% | 899806-45-2 | 5MG | $499.04 | 2021-12-16 | Buy |
| Matrix Scientific | 112751 | 2-(trans-4-Amino-cyclohexyl)-propan-2-ol | 899806-45-2 | 1g | $564 | 2021-12-16 | Buy |
2-(trans-4-Aminocyclohexyl)propan-2-ol Chemical Properties,Uses,Production
Description
2-(trans-4-Aminocyclohexyl)propan-2-ol is a white solid organic heterocyclic compound and a pharmaceutical intermediate component for the synthesis of PIM Kinase Inhibitor TP-3654, which is an orally available second-generation PIM Kinase Inhibitor TP-3654 is an orally available second-generation selective ATP-competitive proviral integration site inhibitor for the treatment of Moloney murine leukaemia virus (PIM) kinase, with potential anti-tumour activity.
Uses
2-(trans-4-Aminocyclohexyl)propan-2-ol can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
Step 1
To a solution of trans-benzyl 4-(dibenzylamino)cyclohexanecarboxylate (290 g X 5, 3.6 mol) in 2 L of THF under N2 at 0 °C, MeMgBr (800 mL) was added. The mixture was stirred at room temperature overnight and then quenched with 1.5 L of saturated NH4Cl. The resulting mixture was extracted wtih EtOAc. The product was extracted with 1 M HCl to the aqueous phase, which was then wash with EtOAc. The aqueous phase was then neutralized with NaOH, extracted with EtOAc, washed with brine, dried with Na2SO4 and concentrated in vacuo to give the 2-(trans-4-(dibenzylamino)cyclohexyl)propan-2-ol. White solid, yield 950 g, 78.3%.
Step 2
A mixture of 2-(trans-4-(dibenzylamino)cyclohexyl)propan-2-ol (120 g X 8,356mmol) and Pd(OH)2 (15g X 8) in methanol (1000 mL) and MeOH/NH3(100 mL) was stirred under H2 (50 psi) at 50 °C for 72 hrs, then the catalyst was removed and the filtrate was concentrated in vacuo and The crude product was chromatographed on silica gel (DCM/MeOH 20:1 - DCM/MeOH/NH3 5:4:1) to give the 2-(trans-4-aminocyclohexyl)propan-2-ol. Yield 210 g, 47.5%, pale yellow solid.
2-(trans-4-Aminocyclohexyl)propan-2-ol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ROSEWA HOLDING GROUP CO.,LIMITED | +86-023-62871537 | sales@rosewachem.com | China | 2828 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10247 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
| Hebei Runbin Biotechnology Co. LTD | 13180553332 | 2179877681@qq.com | CHINA | 996 | 58 |
| Pharmahands (Taizhou) Co., Ltd. | +86 523-86200360 | CHINA | 358 | 58 | |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3465 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5658 | 58 |
View Lastest Price from 2-(trans-4-Aminocyclohexyl)propan-2-ol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-04-08 | TRANS-2-(4-AMINOCYCLOHEXYL)-2-HYDROXYPROPANE
899806-45-2
|
US $45.00 / g/Bag | 1g | 99% | 60kg/month | Pharmahands (Taizhou) Co., Ltd. | |
 |
2020-09-18 | TRANS-2-(4-AMINOCYCLOHEXYL)-2-HYDROXYPROPANE
899806-45-2
|
US $100.00 / KG | 1KG | 99.9% | 20tons | Hebei Runbin Biotechnology Co. LTD |
-
- TRANS-2-(4-AMINOCYCLOHEXYL)-2-HYDROXYPROPANE
899806-45-2
- US $45.00 / g/Bag
- 99%
- Pharmahands (Taizhou) Co., Ltd.
-
- TRANS-2-(4-AMINOCYCLOHEXYL)-2-HYDROXYPROPANE
899806-45-2
- US $100.00 / KG
- 99.9%
- Hebei Runbin Biotechnology Co. LTD
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