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(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol

(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol structure

CAS No.: 17019-46-4

Chemical Name:: (2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol

Synonyms: Erythrofuranosyladenine;9-β-D-Erythrofuranosyladenine;(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol

CBNumber:: CB02648547

Molecular Formula:: C9H11N5O3

Molecular Weight:: 237.21534

MDL Number:: MFCD28016443

MOL File:: 17019-46-4.mol

Last updated:2023-03-31 09:12:58

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(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol Chemical Properties,Uses,Production

Description

Erythrofuranosyladenine, also known as 9-beta-D-Erythrofuranosyladenine and ETA, is a nontoxic MTAP substrate. Erythrofuranosyladenine is an effective salvage agent for methylthioadenosine phosphorylase–selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. The cytotoxicity of EFA to hematopoietic progenitors erythroid burst-forming units (BFU-Es) and granulocyte-macrophage colony-forming units (CFU-GMs) was at least 26- to 41-fold less than that of MTA. EFA selectively rescued MTAP+ MOLT-4 cells from L-alanosine toxicity at 25 microM with negligible toxicity even at 100 microM. EFA is an effective agent for salvaging MTAP+ cells from L-alanosine toxicity and is superior to MTA due to lower cytotoxicity.

(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol Preparation Products And Raw materials

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Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Nanjing Baifuli Technology Co., Ltd.	25-25-58740604 15951658055	sales@unisyn.cn	China	542	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58

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TargetMol Chemicals Inc.	58

(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol 9-β-D-Erythrofuranosyladenine Erythrofuranosyladenine 17019-46-4