ChemicalBook >> CAS DataBase List >>5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride
5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride
- CAS No.
- 1234015-54-3
- Chemical Name:
- 5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride
- Synonyms
- Prexasertib HCl;LY2606368 dihydrochloride;LY2606368 2HCL;LY 2606368;LY-2606368;LY-2606368 (Prexasertib);LY-2606368 dihydrochloride;Prexasertib dihydrochloride;Prexasertib HCl (LY2606368);Prexasertib (LY2606368) 2HCl;Prexasertib 2HCl (LY-2606368)
- CBNumber:
- CB02669661
- Molecular Formula:
- C18H21Cl2N7O2
- Molecular Weight:
- 438.31104
- MDL Number:
- MOL File:
- 1234015-54-3.mol
- MSDS File:
- SDS
Last updated:2023-09-04 15:50:00
5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride Properties
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| solubility | DMSO:12.5(Max Conc. mg/mL);28.52(Max Conc. mM) |
| FDA UNII | 9RFT476U2L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-3507 | Prexasertib(dihydrochloride) 99.41% | 1234015-54-3 | 5mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-3507 | Prexasertib(dihydrochloride) 99.41% | 1234015-54-3 | 10mg | $180 | 2021-12-16 | Buy |
| ApexBio Technology | B8313 | 5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile hydrochloride | 1234015-54-3 | 5mg | $220 | 2021-12-16 | Buy |
| AK Scientific | 4999DG | Prexasertibdihydrochloride | 1234015-54-3 | 50mg | $316 | 2021-12-16 | Buy |
| ApexBio Technology | B8313 | 5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile hydrochloride | 1234015-54-3 | 25mg | $660 | 2021-12-16 | Buy |
5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride Chemical Properties,Uses,Production
Description
Prexasertib HCl is a member of the serine/threonine protein kinase family and is the core protein of cell cycle checkpoints in DNA damage response (DDR).
Biological Activity
Prexasertib HCl is an ATP-competitive inhibitor of CHK1 with a Ki value of 0.9 nM. In cell-free experiments, the IC50 values of it for CHK2 and RSK were 8 nM and 9 nM, respectively.
target
| Target | Value |
| Chk1 (Cell-free assay) | 0.9 nM(Ki) |
| Chk2 (Cell-free assay) | 8 nM | RSK (Cell-free assay) | 9 nM |
5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 70)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Chemtour Biotech Co., Ltd | +8617327281506 | market@chemtour.com | China | 1472 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride Spectrum
1234015-54-3(5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride)Related Search:
5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride
5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile dihydrochloride
LY-2606368 dihydrochloride
Prexasertib (LY2606368) 2HCl
Prexasertib HCl (LY2606368)
Prexasertib dihydrochloride
LY-2606368 (Prexasertib)
LY 2606368;LY-2606368
LY 2606368;LY-2606368;PREXASERTIB DIHYDROCHLORIDE
LY2606368 2HCL
Prexasertib 2HCl (LY-2606368)
LY2606368 dihydrochloride
Prexasertib HCl
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1234015-54-3