Givinostat (hydrochloride)
- CAS No.
- 199657-29-9
- Chemical Name:
- Givinostat (hydrochloride)
- Synonyms
- ITF2357 HCl;Givinostat Hcl;ITF-2357 hydrochloride;Gavinostat hydrochloride;Givinostat (ITF2357) HCl;Givinostat (hydrochloride);Givinostat HCl. gavinostat;Givinostat (ITF2357) hydrochloride;GAVINOSTAT HYDROCHLORIDE;ITF-2357 HYDROCHLORIDE;inhibit,Givinostat hydrochloride,Histone deacetylases,Givinostat,Inhibitor,HDAC
- CBNumber:
- CB03041408
- Molecular Formula:
- C24H28ClN3O4
- Molecular Weight:
- 457.96
- MDL Number:
- MOL File:
- 199657-29-9.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO:45.8(Max Conc. mg/mL);100.01(Max Conc. mM) |
| FDA UNII | Z02132R2QQ |
Givinostat (hydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 6249 | Givinostathydrochloride ≥98%(HPLC) | 199657-29-9 | 5 | $98 | 2021-12-16 | Buy |
| Tocris | 6249 | Givinostathydrochloride ≥98%(HPLC) | 199657-29-9 | 25 | $381 | 2021-12-16 | Buy |
| Crysdot | CD31002770 | Givinostathydrochloride 98+% | 199657-29-9 | 50mg | $251 | 2021-12-16 | Buy |
| Crysdot | CD31002770 | Givinostathydrochloride 98+% | 199657-29-9 | 100mg | $376 | 2021-12-16 | Buy |
Givinostat (hydrochloride) Chemical Properties,Uses,Production
Biological Activity
Givinostat (ITF-2357) hydrochloride is an HDAC inhibitor, inhibits HDAC1 and HDAC3 with IC50 of 198 nM and 157 nM, respectively.
in vitro
Givinostat (hydrochloride) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduces IL-1β secretion more than 70%. Givinostat suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18.
in vivo
Givinostat (ITF2357) at 10 mg/kg is used as a positive control and reduces serum TNFα by 60%. Pretreatment of Givinostat (ITF-2357) starting at 0.1 mg/kg significantly reduces the circulating TNFα by nearly 90%. To achieve a significant increase in serum IL-1β production, a higher dose of LPS is injected (10 mg/kg), and blood is collected after 4 h.
target
| hHDAC3 157 nM (IC 50 ) | hHDAC1 198 nM (IC 50 ) | hHDAC11 292 nM (IC 50 ) | hHDAC6 315 nM ( IC 50 ) | hHDAC2 325 nM (IC 50 ) | hHDAC10 340 nM (IC < sub> 50 ) | hHDAC7 524 nM (IC 50 ) | hHDAC5 532 nM (IC 50 ) | hHDAC9 541 nM (IC 50 ) | hHDAC8 854 nM (IC 50 < /sub> ) | hHDAC4 1059 nM (IC 50 ) | HD1-B 7.5 nM (IC 50 ) | HD1-A 16 nM (IC 50 ) | HD2 10 nM (IC 50 ) |
storage
Store at -20°C
Givinostat (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323967 +86-18015559028 | sales1@artkmedchem.com | China | 39009 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |
| Lanzhou Angeli Biochemical Technology Co., Ltd. | 0931-8235634 13321316780 | 1455540579@qq.com | China | 959 | 55 |