GlyT2-IN-1
- CAS No.
- 448947-81-7
- Chemical Name:
- GlyT2-IN-1
- Synonyms
- Yoda 1;CS-2063;GlyT2-IN-1;GlyT2-IN-1(YODA 1);Yoda1 >=98% (HPLC);Yoda 1 (GlyT2-IN-1);2-((2,6-Dichlorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole;2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine;Pyrazine, 2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-;KcsA,Potassium Channel,Akt,Yoda-1,PKB,Inhibitor,A431 cells,Yoda 1,HCAECs,inhibit,Protein kinase B,ERK,Piezo1,Extracellular signal regulated kinases,Endothelial cells,ERK1/2,Piezo Channel,Yoda1
- CBNumber:
- CB03048654
- Molecular Formula:
- C13H8Cl2N4S2
- Molecular Weight:
- 355.27
- MDL Number:
- MFCD00833175
- MOL File:
- 448947-81-7.mol
| Melting point | 136 - 138°C |
|---|---|
| Boiling point | 538.4±60.0 °C(Predicted) |
| Density | 1.58±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Very Slightly) |
| pka | -1.32±0.10(Predicted) |
| form | powder |
| color | white to beige |
| FDA UNII | TW6GF9RW6S |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
GlyT2-IN-1 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1558 | Yoda1 ≥98% (HPLC) | 448947-81-7 | 5MG | $105 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1558 | Yoda1 ≥98% (HPLC) | 448947-81-7 | 25MG | $424 | 2023-06-20 | Buy |
| Cayman Chemical | 21904 | Yoda1 ≥98% | 448947-81-7 | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 21904 | Yoda1 ≥98% | 448947-81-7 | 5mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 21904 | Yoda1 ≥98% | 448947-81-7 | 10mg | $143 | 2024-03-01 | Buy |
GlyT2-IN-1 Chemical Properties,Uses,Production
Uses
Yoda 1 is a piezo1 channel activator, sensitizes piezo1 to activation by pressure and slows the inactivation phase of transient currents in human embryonic kidney (HEK) cells.
Definition
ChEBI: Yoda 1 is a member of the class of thiadiazoles that is 1,3,4-thiadiazole substituted by pyrazin-2-yl and (2,6-dichlorobenzyl)sulfanediyl groups at positions 2 and 5, respectively. It is a selective activator of mechanosensitive channel piezo1. It has a role as a glycine transporter 2 inhibitor and a piezo1 agonist. It is an aromatic compound, a member of pyrazines, a member of thiadiazoles, an organic sulfide and a dichlorobenzene.
General Description
Yoda1 is a novel synthetic small molecule developed to study the kinetics, regulation and function of the cation channel Piezo-type mechanosensitive ion channel component 1 (Piezo1).
Biochem/physiol Actions
Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.
storage
Store at +4°C
GlyT2-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |