1627710-50-2
- CAS No.
- 1627710-50-2
- Chemical Name:
- 1627710-50-2
- Synonyms
- LJH685;CS-2182;LJH685(LJH-685);LJH-685;LJH 685;LJH685;2,6-Difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]phenol;Phenol, 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]-;LJH685,S6K,LJH-685,Apoptosis,inhibit,Ribosomal S6 Kinase (RSK),LJH 685,Inhibitor
- CBNumber:
- CB03060937
- Molecular Formula:
- C22H21F2N3O
- Molecular Weight:
- 381.42
- MDL Number:
- MOL File:
- 1627710-50-2.mol
| Boiling point | 481.1±45.0 °C(Predicted) |
|---|---|
| Density | 1.257±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | crystalline solid |
| pka | 5.86±0.25(Predicted) |
| FDA UNII | 27CZQ807C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
1627710-50-2 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19913 | LJH685 ≥98% | 1627710-50-2 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19913 | LJH685 ≥98% | 1627710-50-2 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 19913 | LJH685 ≥98% | 1627710-50-2 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 19913 | LJH685 ≥98% | 1627710-50-2 | 25mg | $456 | 2024-03-01 | Buy |
| TRC | L468875 | LJH685 | 1627710-50-2 | 10mg | $625 | 2021-12-16 | Buy |
1627710-50-2 Chemical Properties,Uses,Production
Uses
LJH685 is a selective and potent RSK inhibitor (1). The p90 ribosomal S6 kinase (RSK) family of serine/threonine kinases is linked to various cancers and its substrate phosphorylation is also related to the regulation of cell survival, proliferation, and cell polarity (2).
Biological Activity
ljh685 is a rsk (p90 ribosomal s6 kinase) inhibitor.the p90 ribosomal s6 kinase (rsk) family of serine/threonine kinases is found to be expressed in a variety of cancers and its substrate phosphorylation has been implicated in direct regulation of cell proliferation, cell survival, as well as cell polarity.
in vitro
in a previous study, the structural analysis results confirmed the binding of ljh685 to the rsk2 n-terminal kinase atp-binding site, which suggested that the inhibitor ljh685 adopted an unusual nonplanar conformation that explained its excellent selectivity for rsk family kinases. in addition, ljh685 and it analog lji308 could efficiently inhibit rsk activity in vitro and in cells. moreover, in a subset of examined cell lines, the cellular inhibition of rsk and its phosphorylation of yb1 on ser102 were found to be closely associate with the inhibition of cell growth in an anchorage-independent growth setting [1].
IC 50
6 nm, 5 nm and 4 nm for the biochemical activities of rsk1, rsk2, and rsk3, respectively
References
[1] aronchik i, appleton ba,basham se,crawford k,del rosario m,doyle lv,estacio wf,lan j,lindvall mk,luu ca,ornelas e,venetsanakos e,shafer cm,jefferson ab. novel potent and selective inhibitors of p90 ribosomal s6 kinase reveal the heterogeneity of rsk function in mapk-driven cancers. mol cancer res.2014 may;12(5):803-12.
1627710-50-2 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5791 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |