Sacubitril Sodium
- CAS No.
- 149690-05-1
- Chemical Name:
- Sacubitril Sodium
- Synonyms
- Sacubitril sodium;Valsartan Sodium;Thacubatra sodium;AHU-377 sodium salt;Sacubitril Sodium Salt;AHU-377 (Sacubitril free base);Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate;sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate;(αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt
- CBNumber:
- CB03069990
- Molecular Formula:
- C24H28NNaO5
- Molecular Weight:
- 433.47259
- MDL Number:
- MFCD32004488
- MOL File:
- 149690-05-1.mol
- MSDS File:
- SDS
Last updated:2024-05-22 11:23:49
| Melting point | 163-165°C |
|---|---|
| storage temp. | -20°C, Hygroscopic |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| FDA UNII | MOP72GEP8Z |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H413 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P |
Sacubitril Sodium Chemical Properties,Uses,Production
Description
Sacubitril Sodium is a potent orally active NEP (enkephalinase) inhibitor with an IC50 of 5 nM. Sacubitril Sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril Sodium is a component of the heart failure drug LCZ696. Sacubitril Sodium is used in heart failure, hypertension and COVID-19 studies.
Uses
Sacubitril Sodium Salt is a salt of Sacubitril, an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
Synthesis of Sacubitril Sodium from Succinic anhydride and (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
Sacubitril Sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 77)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Lewoo Pharmatech(Shanghai)Co.,Ltd | +86-15800805830 +86-15800805830 | miao@lewoopharma.com.cn | China | 156 | 58 |
| Apeloa production Co.,Limited | +86-19131931000 +86-19131931000 | admin@apcl.com.cn | China | 249 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
View Lastest Price from Sacubitril Sodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-24 | Sacubitril sodium
149690-05-1
|
US $1.00 / g | 1g | 98% | 1000 | Apeloa production Co.,Limited |
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- Sacubitril sodium
149690-05-1
- US $1.00 / g
- 98%
- Apeloa production Co.,Limited
149690-05-1(Sacubitril Sodium )Related Search:
LCZ696(valsartan + sacubitril) impurity 35
[1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-methyl ester, calcium salt (2:1), (αR,γS)-
LCZ696(valsartan + sacubitril) impurity 31
[1,1'-Biphenyl]-4-pentanoic acid, γ-(acetylamino)-α-methyl-, (αR,γS)-
LCZ696(valsartan + sacubitril) impurity 34
1of2
Sacubitril Sodium Salt
Valsartan Sodium
sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
AHU-377 (Sacubitril free base)
Sacubitril sodium
AHU-377 sodium salt
Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate
Thacubatra sodium
(αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt
149690-05-1