Pimodivir
- CAS No.
- 1629869-44-8
- Chemical Name:
- Pimodivir
- Synonyms
- VX-787;CS-2483;Pimodivir;VRT0928787;VRT 0928787;VRT-0928787;JNJ63623872;JNJ 63623872;JNJ-63623872;Pimodivir (VX-787)
- CBNumber:
- CB03169595
- Molecular Formula:
- C20H19F2N5O2
- Molecular Weight:
- 399.39
- MDL Number:
- MFCD31382121
- MOL File:
- 1629869-44-8.mol
| Density | 1.501±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO, not in water:100.0(Max Conc. mg/mL);250.38(Max Conc. mM) |
| form | A solid |
| pka | 4.32±0.40(Predicted) |
| FDA UNII | DFC121MXC3 |
| NCI Drug Dictionary | pimodivir |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Pimodivir price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29321 | Pimodivir | 1629869-44-8 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 29321 | Pimodivir | 1629869-44-8 | 25mg | $343 | 2024-03-01 | Buy |
| Cayman Chemical | 29321 | Pimodivir | 1629869-44-8 | 10mg | $146 | 2024-03-01 | Buy |
| TRC | P447815 | Pimodivir | 1629869-44-8 | 10mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-6423 | Pimodivir 99.45% | 1629869-44-8 | 10mg | $150 | 2021-12-16 | Buy |
Pimodivir Chemical Properties,Uses,Production
Description
Pimodivir is an inhibitor of influenza virus polymerase basic protein 2 (PB2; KD = <0.003 μM). It also binds to glycogen synthase kinase 3β (GSK3β; Ki = ~1.6 μM) and inhibits the activity of Axl and calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) by greater than 50% in a panel of 65 human and rat kinases. Pimodivir decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC50s = <0.15-2.8 nM in a cell-based assay). It increases the antiviral activity of oseltamivir , zanamivir , and favipiravir (T-705; ) with 50% combination index (CI50) values of 0.58, 0.64, and 0.89, respectively, in a cell-based assay. Pimodivir increases survival in a mouse model of intranasal influenza A infection when administered at doses of 1, 3, and 10 mg/kg twice per day.
Uses
Pimodivir is an orally bioavailable azaindole inhibitor of influenza PB2.
Pimodivir Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Jiangxi Huihe Chemical Co., Ltd. | +86-19189228086 +8618858568638 | wuzhouding@huihecrop.com | China | 886 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |