ethyl (2-(benzo[d]thiazole-2-carboxamido)thiophene-3-carbonyl)carbamate
![ethyl (2-(benzo[d]thiazole-2-carboxamido)thiophene-3-carbonyl)carbamate Structure](CAS/20180527/GIF/864941-32-2.gif)
- CAS No.
- 864941-32-2
- Chemical Name:
- ethyl (2-(benzo[d]thiazole-2-carboxamido)thiophene-3-carbonyl)carbamate
- Synonyms
- ethyl (2-(benzo[d]thiazole-2-carboxamido)thiophene-3-carbonyl)carbamate;Inhibitor,DprE1,Bacterial,inhibit,TCA1,MoeW,Mycobacterium,tuberculosis,oral;Carbamic acid, N-[[2-[(2-benzothiazolylcarbonyl)amino]-3-thienyl]carbonyl]-, ethyl ester
- CBNumber:
- CB03591680
- Molecular Formula:
- C16H13N3O4S2
- Molecular Weight:
- 375.42
- MDL Number:
- MFCD04430653
- MOL File:
- 864941-32-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P |
ethyl (2-(benzo[d]thiazole-2-carboxamido)thiophene-3-carbonyl)carbamate Chemical Properties,Uses,Production
Biological Activity
TCA1 is a small molecule with activity against drug-susceptible and -resistant Mycobacterium tuberculosis (Mtb). TCA1 inhibits enzymes involved in cell wall and molybdenum cofactor biosynthesis, such as DprE1 and MoeW[1]. TCA1 shows bactericidal activity against both replicating (WT and drug resistant) and nonreplicating Mycobacterium tuberculosis (Mtb). TCA1 inhibits biofilm formation by Mtb H37Rv[1]. TCA1 shows selective inhibitory activity against bacterial growth-it is inactive against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, suggesting that the target for its bactericidal activity is specific to the genus Mycobacterium[1]. TCA1 (40 mg/kg; oral gavage; 1 time/d for 5 d/week; for 4 weeks) is efficacious in acute and chronic Mtb infection mouse models[1].In a mouse model of Mtb infection, after i.v. administration, TCA1 exhibits a low clearance and steady-state volume of distribution, with an elimination half-life of 0.73 h. After oral administration of 20 and 50 mg/kg in solution formulation, TCA1 shows a high Cmax (2122 and 5653 nM, respectively), moderate exposure with oral bioavailability ranging from 19% to 46%, and a half-life of 1.8 h[1].BALB/c mice infected with Mtb H37Rv[1]40 mg/kgOral gavage; 1 time/d for 5 d/week; for 4 weeksEffectively inhibits Mtb in vivo.
References
[1]. Feng Wang, et al. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2510-7.
ethyl (2-(benzo[d]thiazole-2-carboxamido)thiophene-3-carbonyl)carbamate Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl (2-(benzo[d]thiazole-2-carboxamido)thiophene-3-carbonyl)carbamate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 9946 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| cjbscvictory | 58 |
| TargetMol Chemicals Inc. | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 58 |