Baloxavir
- CAS No.
- 1985605-59-1
- Chemical Name:
- Baloxavir
- Synonyms
- (R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione;S-033447;CPD2051;Baloxavir;New Baloxavir;Baloxavir (Xofluza;Baloxavir USP/EP/BP;Baloxavir Impurity 10;BXA,endonuclease,S033447,Influenza Virus;influenza,RNA,inhibit,dolutegravir,Baloxavir,Inhibitor,cap-dependent,S 033447,CEN,transcription,replication
- CBNumber:
- CB04662930
- Molecular Formula:
- C24H19F2N3O4S
- Molecular Weight:
- 483.49
- MDL Number:
- MFCD31619273
- MOL File:
- 1985605-59-1.mol
| Boiling point | 644.7±65.0 °C(Predicted) |
|---|---|
| Density | 1.63±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:41.67(Max Conc. mg/mL);86.19(Max Conc. mM) |
| form | A solid |
| pka | 4.50±1.00(Predicted) |
| CAS DataBase Reference | 1985605-59-1 |
| FDA UNII | 4G86Y4JT3F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Baloxavir price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0039267 | Baloxavir 98.92% | 1985605-59-1 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0039267 | Baloxavir 98.92% | 1985605-59-1 | 10mg | $650 | 2021-12-16 | Buy |
| ChemScene | CS-0039267 | Baloxavir 98.92% | 1985605-59-1 | 25mg | $1250 | 2021-12-16 | Buy |
| ChemScene | CS-0039267 | Baloxavir 98.92% | 1985605-59-1 | 50mg | $1950 | 2021-12-16 | Buy |
| ChemScene | CS-0039267 | Baloxavir 98.92% | 1985605-59-1 | 100mg | $3000 | 2021-12-16 | Buy |
Baloxavir Chemical Properties,Uses,Production
Uses
Baloxavir is a drug employed in the treatment of influenza virus infection.
Baloxavir marboxil is a selective inhibitor of influenza cap-dependent endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains resistant to current antiviral agents.
Uses
Baloxavir is a drug employed in the treatment of influenza virus infection.
Mechanism of action
Baloxavir marboxil is an influenza therapeutic agent, specifically, an enzyme inhibitor targeting the influenza virus' cap-dependent endonuclease activity, one of the activities of the virus polymerase complex. In particular, it inhibits a process known as cap snatching, by which the virus derives short, capped primers from host cell RNA transcripts, which it then uses for polymerase-catalyzed synthesis of its needed viral mRNAs. A polymerase subunit binds to the host pre-mRNAs at their 5' caps, then the polymerase's endonuclease activity catalyzes its cleavage "after 10–13 nucleotides". As such, its mechanism is distinct from neuraminidase inhibitors such as oseltamivir and zanamivir.
Side effects
Common side effects following the single dose administration of baloxavir marboxil include diarrhea, bronchitis, common cold, headache, and nausea. Adverse events were reported in 21% of people who received baloxavir, 25% of those receiving placebo, and 25% of oseltamivir.
Baloxavir Preparation Products And Raw materials
Raw materials
Preparation Products
Baloxavir Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Heading （Nanjing）Pharmtechnologies Co., Ltd. | +86-25-58467899-832 +86-13382406280 | liucheng@headingpharm.com | China | 46 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 1125 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8348 | 58 |
| Xi'an Yutbon Pharmaceutical Technology Co., Ltd | 029-81140587 +8618717328141 | sales@yutbon.com | China | 453 | 58 |
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View Lastest Price from Baloxavir manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-18 | Baloxavir
1985605-59-1
|
US $0.00 / kg | 1kg | 99% | 10000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | |
 |
2024-03-28 | Baloxavir
1985605-59-1
|
US $0.00 / kg | 25kg | 98% | Inquiry | PNP Biotech Co. Ltd | |
 |
2023-08-22 | Baloxavir
1985605-59-1
|
US $25.00 / kg | 1kg | 99% | 100tons | Anhui Ruihan Technology Co., Ltd |