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MC180295

MC180295 structure

CAS No.: 2237942-08-2

Chemical Name:: MC180295

Synonyms: MC180295;(rel)-MC180295;MC-180295;MC 180295;MC180295 ((REL)-MC180295);MC180295,MC 180295,Cyclin dependent kinase,MC-180295,CDK,inhibit,Inhibitor;Methanone, [4-amino-2-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]-5-thiazolyl](2-nitrophenyl)-, rel-

CBNumber:: CB04923806

Molecular Formula:: C17H18N4O3S

Molecular Weight:: 358.41

MDL Number:: MFCD31924820

MOL File:: 2237942-08-2.mol

Last updated:2023-05-21 10:59:17

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MC180295 Properties

Boiling point	623.8±65.0 °C(Predicted)
Density	1.462±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (279.01 mM)
pka	2.40±0.10(Predicted)

MC180295 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0081067	MC180295 98.47%	2237942-08-2	5mg	$650	2021-12-16	Buy
ChemScene	CS-0081067	MC180295 98.47%	2237942-08-2	10mg	$950	2021-12-16	Buy
Biorbyt Ltd	orb573229	MC180295 >98%	2237942-08-2	100mg	$1802	2021-12-16	Buy
ChemScene	CS-0081067	MC180295 98.47%	2237942-08-2	50mg	$2850	2021-12-16	Buy
Biorbyt Ltd	orb573229	MC180295 >98%	2237942-08-2	250mg	$3136.5	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0081067	5mg	$650	Buy
CS-0081067	10mg	$950	Buy
orb573229	100mg	$1802	Buy
CS-0081067	50mg	$2850	Buy
orb573229	250mg	$3136.5	Buy

MC180295 Chemical Properties,Uses,Production

Uses

MC180295 can be useful in combination therapy of BET proteolysis targeting chimeric mol. with CDK9 inhibitor against human multiple myeloma cells.

Biological Activity

MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with IC50 of 5 nM, at least 22-fold selective for CDK9 over other CDKs.

in vivo

MC180295 has antitumor and immunoallergic activity.

target

Target	Value
CDK9-Cyclin T1 (Cell-free assay)	5 nM
CDK4-Cyclin D (Cell-free assay)	112 nM
CDK1-Cyclin B (Cell-free assay)	138 nM
CDK5-P35 < br/> (Cell-free assay)	159 nM
CDK5-P25 (Cell-free assay)	186 nM

MC180295 Preparation Products And Raw materials

Raw materials

Preparation Products

MC180295 Suppliers

Global( 25)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai Jiyi Biological Technology Co., LTD	021-54135696 18516235431	shgegenetech@163.com	China	986	55
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3423	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7892	56
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9730	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58

Supplier	Advantage
Career Henan Chemica Co	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Shanghai Jiyi Biological Technology Co., LTD	55
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
ShangHai Biochempartner Co.,Ltd	62
Fan De(Beijing) Biotechnology Co., Ltd.	58
DC Chemicals	58

MC180295 ((REL)-MC180295) MC180295 MC-180295;MC 180295 (rel)-MC180295 Methanone, [4-amino-2-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]-5-thiazolyl](2-nitrophenyl)-, rel- MC180295,MC 180295,Cyclin dependent kinase,MC-180295,CDK,inhibit,Inhibitor 2237942-08-2