ChemicalBook >> CAS DataBase List >>BPAM344 >=98% (HPLC)
BPAM344 >=98% (HPLC)
- CAS No.
- 1204572-55-3
- Chemical Name:
- BPAM344 >=98% (HPLC)
- Synonyms
- BPAM-344;BPAM344 >=98% (HPLC);2H-1,2,4-Benzothiadiazine, 4-cyclopropyl-7-fluoro-3,4-dihydro-, 1,1-dioxide;Ionotropic glutamate receptors,GluK3a,PAM,iGluR,BPAM344,BPAM 344,Inhibitor,BPAM-344,KAR,GluK1b,GluK2a,inhibit
- CBNumber:
- CB08323468
- Molecular Formula:
- C10H11FN2O2S
- Molecular Weight:
- 242.27
- MDL Number:
- MOL File:
- 1204572-55-3.mol
Last updated:2023-09-20 16:43:00
BPAM344 >=98% (HPLC) Chemical Properties,Uses,Production
Biological Activity
BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM)[1]. BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics[1]. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold)[1].
References
[1]. Anja Probst Larsen, et al. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol Pharmacol. 2017 Jun;91(6):576-585.
BPAM344 >=98% (HPLC) Preparation Products And Raw materials
Raw materials
Preparation Products
BPAM344 >=98% (HPLC) Suppliers
Global( 14)Suppliers
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|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
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| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
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| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80514535 19917294565 | caoy@chemextension.com | China | 3090 | 58 |
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| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
BPAM344 >=98% (HPLC)
BPAM-344
Ionotropic glutamate receptors,GluK3a,PAM,iGluR,BPAM344,BPAM 344,Inhibitor,BPAM-344,KAR,GluK1b,GluK2a,inhibit
2H-1,2,4-Benzothiadiazine, 4-cyclopropyl-7-fluoro-3,4-dihydro-, 1,1-dioxide
1204572-55-3