ChemicalBook >> CAS DataBase List >>1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- structure

CAS No.: 1227098-15-8

Chemical Name:: 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-

Synonyms: NF-κB-IN-1;AC17 NF-κB-IN-1;NF-kB-IN-1(AC17);(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4-(4-hydroxy-3-methoxybenzylidene)hepta-1,6-diene-3,5-dione;1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-;pathway,4-arylidene,Inhibitor,inhibit,IKK,crucumin,cancer,A549,NFκBIN1,I kappa B kinase,signaling,NF κB IN 1,IκB kinase,NF-κB

CBNumber:: CB08367286

Molecular Formula:: C31H30O8

Molecular Weight:: 530.57

MDL Number:

MOL File:: 1227098-15-8.mol

Last updated:2023-09-20 16:43:00

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1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Properties

Boiling point	732.0±60.0 °C(Predicted)
Density	1.233±0.06 g/cm3(Predicted)
pka	9.27±0.31(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0148832	NF-κB-IN-1	1227098-15-8	5mg	$480	2021-12-16	Buy
ChemScene	CS-0148832	NF-κB-IN-1	1227098-15-8	10mg	$800	2021-12-16	Buy
ChemScene	CS-0148832	NF-κB-IN-1	1227098-15-8	25mg	$1550	2021-12-16	Buy
ChemScene	CS-0148832	NF-κB-IN-1	1227098-15-8	50mg	$2400	2021-12-16	Buy
ChemScene	CS-0148832	NF-κB-IN-1	1227098-15-8	100mg	$3600	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0148832	5mg	$480	Buy
CS-0148832	10mg	$800	Buy
CS-0148832	25mg	$1550	Buy
CS-0148832	50mg	$2400	Buy
CS-0148832	100mg	$3600	Buy

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Chemical Properties,Uses,Production

Biological Activity

NF-κB-IN-1, a 4-arylene curcumin analog, is a potent NF-κB signaling pathway inhibitor. It directly inhibits IKK to block NF-κB activation. It can effectively inhibit the viability of lung cancer cells and attenuate the clonal activity of A549 cells.

in vitro

NF-κB-IN-1 (compound 17) (0.001-100 μM; 72 h) inhibits the growth of A549, H1944, H460 and H157 cells, with GI ₅₀ s of 0.72, 0.07, 0.13, and 0.16 μM, respectively.

target

IKK

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Preparation Products And Raw materials

Raw materials

Preparation Products

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Suppliers

Global( 15)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3501	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Henan Weituxi Chemical Technology Co., Ltd.	0371-63284658 18135795563	2885349392@qq.com	China	9999	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	29778	58
Bide Pharmatech Ltd.	400-1647117 15221909166	product02@bidepharm.com	China	63720	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58

Supplier	Advantage
InvivoChem	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Tianjin Kailiqi Biotechnology Co., Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Henan Weituxi Chemical Technology Co., Ltd.	58
DC Chemicals	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Spectrum

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-(1227098-15-8)¹HNMR

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- AC17 NF-κB-IN-1 NF-κB-IN-1 NF-kB-IN-1(AC17) (1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4-(4-hydroxy-3-methoxybenzylidene)hepta-1,6-diene-3,5-dione pathway,4-arylidene,Inhibitor,inhibit,IKK,crucumin,cancer,A549,NFκBIN1,I kappa B kinase,signaling,NF κB IN 1,IκB kinase,NF-κB 1227098-15-8