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UMB298

UMB298 structure

CAS No.: 2266569-73-5

Chemical Name:: UMB298

Synonyms: UMB298;UMB-298,UMB298,inhibit,MOLM13,Inhibitor,bromodomain,UMB 298,selective,potent,Epigenetic Reader Domain,CBP30;Imidazo[1,2-a]pyridin-3-amine, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-N-cyclohexyl-7-(3,5-dimethyl-4-isoxazolyl)-

CBNumber:: CB09401947

Molecular Formula:: C27H31ClN4O2

Molecular Weight:: 479.01

MDL Number:: MFCD34474161

MOL File:: 2266569-73-5.mol

Last updated:2023-05-21 10:59:17

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UMB298 Properties

Density	1.29±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 25 mg/mL (52.19 mM; Need ultrasonic)
pka	7.87±0.50(Predicted)

UMB298 Chemical Properties,Uses,Production

Biological Activity

UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1]. UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth[1].UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia[1].UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression[1].

References

[1]. Muthengi A, et al. Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors. J Med Chem. 2021;64(9):5787-5801.

UMB298 Preparation Products And Raw materials

Raw materials

Preparation Products

UMB298 Suppliers

Global( 10)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4153	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9767	58
Fujian boshi pharmaceutical technology co. LTD	18120708884	393612455@qq.com	China	255	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58
https://hanhongsci.com/	021-54306202 18917919676	info@hanhongsci.com	China	29989	58
Changsha Fuzhen Biotechnology Co.，LTD	0731-18670069958 18670069958	184792226@qq.com	China	3060	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9180	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	12007	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58
Fujian boshi pharmaceutical technology co. LTD	58
TargetMol Chemicals Inc.	58
https://hanhongsci.com/	58
Changsha Fuzhen Biotechnology Co.，LTD	58
RD International Technology Co., Limited	58
Nanjing Shizhou Biology Technology Co.,Ltd	58

UMB298 UMB-298,UMB298,inhibit,MOLM13,Inhibitor,bromodomain,UMB 298,selective,potent,Epigenetic Reader Domain,CBP30 Imidazo[1,2-a]pyridin-3-amine, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-N-cyclohexyl-7-(3,5-dimethyl-4-isoxazolyl)- 2266569-73-5