1H-INDOLE-5-CARBOXAMIDE, 97%
- CAS No.
- 1670-87-7
- Chemical Name:
- 1H-INDOLE-5-CARBOXAMIDE, 97%
- Synonyms
- SD-169;5-CarbaMoylindole;5-(AMinocarbonyl)-1H-indole;1H-Indole-5-carboxamide(9CI);1H-INDOLE-5-CARBOXAMIDE, 97%;1H-indole-5-carboxamide(SD-169);Indole-5-carboxamide (7CI, 8CI);p38 MAP Kinase Inhibitor VII, SD-169;p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem;5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole
- CBNumber:
- CB0972248
- Molecular Formula:
- C9H8N2O
- Molecular Weight:
- 160.17
- MDL Number:
- MFCD07779486
- MOL File:
- 1670-87-7.mol
- MSDS File:
- SDS
| Melting point | 159-163 °C |
|---|---|
| Boiling point | 457.6±18.0 °C(Predicted) |
| Density | 1.328±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 16.25±0.30(Predicted) |
| form | Off-white solid |
| color | Off-White to Light Purple |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| NFPA 704 |
|
1H-INDOLE-5-CARBOXAMIDE, 97% price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 506158 | p38 MAP Kinase Inhibitor VII, SD-169 | 1670-87-7 | 10mg | $216 | 2024-03-01 | Buy |
| Cayman Chemical | 14156 | SD 169 ≥97% | 1670-87-7 | 5mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 14156 | SD 169 ≥97% | 1670-87-7 | 10mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 14156 | SD 169 ≥97% | 1670-87-7 | 25mg | $142 | 2024-03-01 | Buy |
| TRC | I615500 | 1H-Indole-5-carboxamide | 1670-87-7 | 10g | $950 | 2021-12-16 | Buy |
1H-INDOLE-5-CARBOXAMIDE, 97% Chemical Properties,Uses,Production
Uses
1H-Indole-5-carboxamide (SD-169) is a p38α MAPK-selective inhibitor. 1H-Indole-5-carboxamide (SD-169) prevents the development and progression of diabetes in nonobese diabetic (NOD) mice by inhibiting T cell infiltration and activation.
Uses
SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM). It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM. SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg. In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis. SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.
Definition
ChEBI: 1H-indole-5-carboxamide is an indolecarboxamide.
Biological Activity
Selective, orally active, ATP-competitive inhibitor of p38 α MAPK (IC 50 values are 3.2, 122 and > 50000 nM for p38 α , p38 β and p38 γ respectively). Demonstrates no activity against a range of other kinases including ERK2, JNK1 and MAPKAP2. Prevents development of diabetes and alleviates mild and moderate hyperglycaemic states in NOD mice.
References
[1] medicherla s, protter a a, ma j y, et al. preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes[j]. journal of pharmacology and experimental therapeutics, 2006, 318(1): 99-107.
[2] myers r r, sekiguchi y, kikuchi s, et al. inhibition of p38 map kinase activity enhances axonal regeneration[j]. experimental neurology, 2003, 184(2): 606-614.
1H-INDOLE-5-CARBOXAMIDE, 97% Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Nanjing jinheyou Trading Co., Ltd. | 15705188088 | admin@jheyou.com | CHINA | 1268 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1250 | 58 |
View Lastest Price from 1H-INDOLE-5-CARBOXAMIDE, 97% manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | 1H-INDOLE-5-CARBOXAMIDE, 97%
1670-87-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-01-13 | 1H-INDOLE-5-CARBOXAMIDE
1670-87-7
|
US $1.00 / g | 1g | 98% | 100KG | Career Henan Chemical Co | |
 |
2019-12-23 | 1H-INDOLE-5-CARBOXAMIDE, 97%
1670-87-7
|
US $0.00 / g | 1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. |
-
- 1H-INDOLE-5-CARBOXAMIDE, 97%
1670-87-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1H-INDOLE-5-CARBOXAMIDE
1670-87-7
- US $1.00 / g
- 98%
- Career Henan Chemical Co
-
- 1H-INDOLE-5-CARBOXAMIDE, 97%
1670-87-7
- US $0.00 / g
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
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