NPS 2390
- CAS No.
- 226878-01-9
- Chemical Name:
- NPS 2390
- Synonyms
- N-(1-adamantyl)quinoxaline-2-carboxamide;N-(Adamantan-1-yl)quinoxaline-2-carboxamide;N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide;2-Quinoxalinecarboxamide, N-tricyclo[3.3.1.13,7]dec-1-yl-;Inhibitor,NPS2390,Calcium-sensing receptor,NPS-2390,mGluR,inhibit,Metabotropic glutamate receptors,CaSR,NPS 2390
- CBNumber:
- CB0972884
- Molecular Formula:
- C19H21N3O
- Molecular Weight:
- 307.39
- MDL Number:
- MFCD05865239
- MOL File:
- 226878-01-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
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NPS 2390 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11989 | NPS 2390 ≥98% | 226878-01-9 | 5mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 11989 | NPS 2390 ≥98% | 226878-01-9 | 10mg | $168 | 2024-03-01 | Buy |
| Cayman Chemical | 11989 | NPS 2390 ≥98% | 226878-01-9 | 25mg | $395 | 2024-03-01 | Buy |
| TRC | N899033 | NPS2390 | 226878-01-9 | 1mg | $45 | 2021-12-16 | Buy |
| TRC | N899033 | NPS2390 | 226878-01-9 | 5mg | $75 | 2021-12-16 | Buy |
NPS 2390 Chemical Properties,Uses,Production
Description
Metabotropic glutamate receptors (mGluRs), mediate excitatory synaptic transmission in the central nervous system. Potent and selective antagonists of the type I mGluRs (mGluR1 and mGluR5) are of interest as novel therapeutics for the treatment of various CNS disorders, such as pain, epilepsy, and stroke. NPS 2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 with IC50 values equal to 5.2 and 82 nM, respectively). At concentrations up to 30 μM, NPS 2390 does not affect mGluR2 or mGluR8 or a standard collection of 37 additional receptors, ion channels, and enzymes. At a dose of 10 mg/kg, NPS 2390 displaced the specifically bound mGlu1R-
Uses
NPS 2390 is an inhibitor of CaSR (Calcium-sensing recpetor). NPS 2390 up-regulated anti-apoptotic protein Bcl-2 expression and down-regulated pro-apoptotic protein Bax.
Uses
Metabotropic glutamate receptors (mGluRs), mediate excitatory synaptic transmission in the central nervous system. Potent and selective antagonists of the type I mGluRs (mGluR1 and mGluR5) are of interest as novel therapeutics for the treatment of various CNS disorders, such as pain, epilepsy, and stroke. NPS 2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 with IC50 values equal to 5.2 and 82 nM, respectively). At concentrations up to 30 μM, NPS 2390 does not affect mGluR2 or mGluR8 or a standard collection of 37 additional receptors, ion channels, and enzymes. At a dose of 10 mg/kg, NPS 2390 displaced the specifically bound mGlu1R-selective antagonist, [3H]R214127, in rat cerebellum.
storage
Store at RT
NPS 2390 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Atomic chemistry | 0370-2785705 19339619972 | 2234585634@qq.com | China | 4175 | 58 |
| DKMbiochem.Co. Ltd | 15901859516 | sales@DKMbiochem.com | China | 344 | 58 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2031 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |