Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]-
![Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]- Structure](CAS/20210305/GIF/1971937-18-4.gif)
- CAS No.
- 1971937-18-4
- Chemical Name:
- Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]-
- Synonyms
- ARN19702;ARN19702,ARN-19702;Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]-
- CBNumber:
- CB09788907
- Molecular Formula:
- C21H22FN3O3S2
- Molecular Weight:
- 447.55
- MDL Number:
- MOL File:
- 1971937-18-4.mol
Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]- Chemical Properties,Uses,Production
Biological Activity
ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 230 nM for human NAAA. ARN19702 has pain relief effects[1][2]. ARN19702 (3-10 mg/kg; po; daily; for 7 consecutive days) reduces nociception associated with Paclitaxel-induced neuropathy without development of subacute antinociceptive tolerance in male rats[1]. In male mice, ARN19702 (0.1-30 mg/kg; po) attenuates in a dose-dependent manner the spontaneous nocifensive response elicited by intraplantar formalin injection and the hypersensitivity caused by intraplantar carrageenan injection, paw incision, or sciatic nerve ligation[1].. ARN19702 (3-10 mg/kg; po) produces remarkable protective effects against multiple sclerosis in mice[2].Pharmacokinetic properties of ARN19702 in mice 3 mg/kg,i.v 3 mg/kg, p.o. Cmax (ng/mL)1660±166613±68 Tmax (min)(5.0)30 CL (mL/min/Kg)33.2±1.649±8 t1/2 (min)73.9±3.7104±16 AUCplasma (h×ng/mL)1366.8±68.3988±157 AUCbrain (h×ng/mL)404.3±109.1181±28 F (%)-72±11
References
[1]. Yannick Fotio, et al. Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone, a Novel Orally Active N-Acylethanolamine Acid Amidase Inhibitor, in Animal Models. J Pharmacol Exp Ther. 2021 Aug;378(2):70-76. [2]. Marco Migliore Dr, et al. Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis. Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11193-11197.
Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Meike meditech (Foshan) Co.,Ltd | +86-0757-22239986 +86-18029359586 | sales@mkmeditech.com | China | 1134 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9767 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4191 | 58 |
| MeiKe medicine technology (Foshan City) Co., LTD | 18029359586 | sales@mkmeditech.com | China | 838 | 58 |
| https://hanhongsci.com/ | 021-54306202 18917919676 | info@hanhongsci.com | China | 29989 | 58 |