Ristocetin A sulfate
- CAS No.
- 11140-99-1
- Chemical Name:
- Ristocetin A sulfate
- Synonyms
- RISTON;SPONTIN;RISTOMYCIN;RISTOCETIN A;RISTOCETINSULFATQ;ristomycin,sulfate;RISTOCETIN SULFATE;RISTOCETIN A SULFATE;Ristocetin A sulphate;RISTOMYCIN MONOSULFATE
- CBNumber:
- CB1251133
- Molecular Formula:
- C95H112N8O48S
- Molecular Weight:
- 2166
- MDL Number:
- MFCD00076121
- MOL File:
- 11140-99-1.mol
- MSDS File:
- SDS
| Melting point | >200°C (dec.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Water (Slightly) |
| form | Light tan solid. |
| color | White to Pale Beige |
| Stability | Hygroscopic |
| EWG's Food Scores | 1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Warning |
| Hazard statements | H314 |
| Precautionary statements | P264b-P271-P280-P301+P330+P331-P304+P340-P305+P351+P338-P310-P363-P403+P233-P501c |
| Hazard Codes | Xi |
| Risk Statements | 36/38 |
| Safety Statements | 22-24/25-37/39-26 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | VJ8650000 |
| F | 8-10-23 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | mouse,LD50,intravenous,660mg/kg (660mg/kg),BEHAVIORAL: TREMORLUNGS, THORAX, OR RESPIRATION: OTHER CHANGESBEHAVIORAL: EXCITEMENT,Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and Medical Biotechnology. Vol. 32, Pg. 910, 1987. |
Ristocetin A sulfate price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R7752 | Ristomycin monosulfate ≥90% ristocetinA basis (balance primarily RistocetinB) | 11140-99-1 | 100mg | $655 | 2024-03-01 | Buy |
| Sigma-Aldrich | R7752 | Ristomycin monosulfate ≥90% ristocetinA basis (balance primarily RistocetinB) | 11140-99-1 | 250mg | $1460 | 2024-03-01 | Buy |
| Usbiological | R2032-22 | Ristocetin A Sulfate | 11140-99-1 | 10mg | $513 | 2021-12-16 | Buy |
| TRC | R530000 | RistomycinMonosulfate(90%) | 11140-99-1 | 1mg | $55 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR45311 | Ristocetin sulfate - mixture of A & B | 11140-99-1 | 5mg | $73 | 2021-12-16 | Buy |
Ristocetin A sulfate Chemical Properties,Uses,Production
Uses
Ristocetin A sulfate is a potent antibacterial glycopeptide antibiotic that was withdrawn from clinical use following a high incidence of thrombocytopenia. Further investigation found that ristocetin A induced platelet aggregation by binding to a factor absent in people suffering from von Willebrand's disease, leading to the use of ristocetin A as an important diagnostic aid.
Uses
Ristomycin Monosulfate is used in biological studies for ligand discovery of fluorescent HIV-1 Dimerization Initation Site.
General Description
Ristomycin/ristocetin is a type III glycopeptide. It is a highly glycosylated glycopeptide, previously found in?Amycolatopsis lurida.
Biological Activity
ristocetin a, a glycopeptide related to vancomycin, is an antibiotic produced by the microorganism nocardia lurida[1].ristocetin a is currently in clinical use to treat bacterial infections [1]. ristocetin a is an antibiotic which can be used to treat staphylococcal infections. the side effects of ristocetin a include thrombocytopenia and platelet agglutination. ristocetin a has been used in two assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. these two assays could be used to diagnosis the von willebrand disease and other bleeding disorders [2, 3]. the structural features of ristocetin a are similar to vancomycin.
Biochem/physiol Actions
Ristocetin activates platelets. Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis. Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia. Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes suporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals.
References
[1] pearson a j, heo j n. approaches to the fully functionalized def ring system of ristocetin a via highly selective ruthenium-promoted snar reaction[j]. organic letters, 2000, 2(19): 2987-2990.hawks g h. antibiotic therapy of staphylococcal infections[j]. canadian medical association journal, 1965, 93(16): 848.
[3] castaman, g. ,hillarp, a. and goodeve, a. laboratory aspects of von willebrand disease: test repertoire and options for activity assays and genetic analysis. haemophilia 20(suppl 4), 65-70 (2014).
Ristocetin A sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 18521735133 18521732826; | market@aladdin-e.com | China | 25014 | 65 |
View Lastest Price from Ristocetin A sulfate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | RISTOCETIN SULFATE SALT
11140-99-1
|
US $1.00 / KG | 1G | 98% | 100KG | Career Henan Chemical Co |
-
- RISTOCETIN SULFATE SALT
11140-99-1
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
11140-99-1(Ristocetin A sulfate)Related Search:
1of4