Epitalon

Epitalon Properties

Boiling point	959.8±65.0 °C(Predicted)
Density	1.466±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 250 mg/mL (495.67 mM)
pka	3.16±0.10(Predicted)
Sequence	Ala-Glu-Asp-Gly
InChIKey	HGHOBRRUMWJWCU-VTCOHLDGNA-N
SMILES	[C@H](CC(=O)O)(C(=O)NCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)C \|&1:0,15,24,r\|
FDA UNII	O65P17785G

Epitalon price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0028299	Epitalon	307297-39-8	1mg	$65	2021-12-16	Buy
ChemScene	CS-0028299	Epitalon	307297-39-8	5mg	$195	2021-12-16	Buy
ChemScene	CS-0028299	Epitalon	307297-39-8	10mg	$350	2021-12-16	Buy
ChemScene	CS-0028299	Epitalon	307297-39-8	25mg	$750	2021-12-16	Buy
Biorbyt Ltd	orb611973	Epitalon >98%	307297-39-8	100mg	$1060.8	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0028299	1mg	$65	Buy
CS-0028299	5mg	$195	Buy
CS-0028299	10mg	$350	Buy
CS-0028299	25mg	$750	Buy
orb611973	100mg	$1060.8	Buy

Epitalon Chemical Properties,Uses,Production

Description

Epitalon (also known as Epithalon or Epithalone) is the synthetic version of the polypeptide Epithalamin which is naturally produced in the pineal gland. It was synthesized by Vladimir Khavinson, a Russian professor and gerontologist, whose research focused on the development of peptide preparations used to restore function in various organs in order to prevent and reverse the aging process. He is currently the Director of the Saint Petersburg Institute of Bioregulation and Gerontology.
Epitalon is considered the "fountain of youth" peptide. It is a tetra-peptide, which means that it is composed of four amino acid chains. The peptide is used to regulate the cell cycle during telomerase activity. Telomerase, also called telomere terminal transferase, is an enzyme made of protein and RNA subunits that elongates chromosomes. When telomerase activity is not present (when we age), our cells age. Our telomeres get shorter and begin to die off. If telomerase is activated in our cells, our telomeres lengthen, the cell continues to grow and divide, delaying the aging process. (UT Southwestern Medical Lab)
https://www.amisantabarbara.com/epitalon

History

Epitalon was discovered and developed by the Russian scientist and gerontologist Professor, Doctor of Medical sciences Vladimir Khavinson of St. Petersburg Institute of Bioregulation and Gerontology, whose research is focused on the development of peptide preparations used to restore function in various organs in order to prevent and reverse the aging process. Epitalon was identified as active component of a bovine pineal gland extract (known as Epithalamin).
Low-molecular peptides isolated from pineal gland and Epithalamin of animals were studied in different biologic models. Most all performed scientific studies and clinical trials of Epitalon and Epithalamin have been conducted just by already mentioned St. Petersburg Institute of Bioregulation and Gerontology in Russia, primarily overseen by Professor Vladimir Khavinson, who has been involved in this research already for over 35 years, and has merit not only in the discovery of epitalon, but also in its highly advanced scientific and clinical review. Throughout this time, Epitalon has been extensively investigated in animal and human clinical trials and today is one of the best scientifically investigated peptides.
https://beringomega.org

Uses

Epitalon is a synthetic peptide made of four amino acids (alanine, glutamic acid, aspartic acid, and glycine), that is based on a natural peptide called epithalamin extracted from the pineal gland. It was synthesized by Vladimir Khavinson, a Russian professor and gerontologist, whose research focused on the development of peptide preparations used to restore function in various organs in order to prevent and reverse the aging process. He is currently the Director of the Saint Petersburg Institute of Bioregulation and Gerontology.

benefits

As a result of Epitalon’s effect on telomerase production, the benefits are unique and far-reaching and include:
Increases lifespan by lengthening telomeres in human cells|
Promotes deeper sleep
Delays and prevents of age-related diseases such as cancer, heart disease, and dementia
Acts as an antioxidant by reducing lipid oxidation and ROS (Reactive oxygen species) along with normalizing T cell function
Improves skin health and appearance
Heals injured and deteriorating muscle cells
Restores and normalizes melatonin levels in those who have lost some pineal function due to aging
Can increase resistance to emotional stress

Biological Functions

Epitalon was discovered by the Russian scientist Professor Vladimir Khavinson. He researched this peptide of over 35 years in both animal and human clinical trials. The results were astounding. For the first time ever, human clinical trials proved beyond doubt that the substance consisted of powerful life extension and anti-aging possibilities.
Benefits of Epitalon: As a result of Epitalon's effect on telomerase production, the benefits are unique and far-reaching and include:
An increase of human lifespan by lengthening telomeres in human cells
Promotion of deeper sleep
Delay and prevention of age-related diseases such as cancer, heart disease, and dementia
Acts as an anti-oxidant by reducing lipid oxidation and ROS (Reactive oxygen species) along with normalizing T cell function.
Improvement of skin health and appearance
Healing of injured and deteriorating muscle cells
Restores and normalizes melatonin levels in older people who have lost some pineal function due to aging
Can increases resistance to emotional stress

Mechanism of action

Telomerase activator peptide Epitalon directly stimulates cells in the body to produce a telomerase enzyme, that renew and extends telomeres at the ends of chromosomes. This ultimately leads to a slowing of the aging of cell populations, and the aging of cell populations correlate with the overall physical aging of an organism. Clinical studies conducted with Epitalon have shown that administration of Epitalon to mammals has not only reversed the symptoms of aging but also reversed many age-related diseases. Epitalon has also been shown to help restore and normalize melatonin production by the pineal gland, as well as restoring the normal circadian rhythm of cortisol production, both of which result in better sleep at night.

Side effects

Epithalon side effects are very uncommon.
Side effects associated with epithalon may include the following:
Diarrhea
Difficulty sleeping
Fatigue
Flu-like symptoms
Headache
Irregular heartbeat
Joint pain
Nausea

Clinical claims and research

Tetrapeptide Epitalon® (Ala–Glu–Asp–Gly) was designed on the basis of Epithalamin amino acid analysis and synthesized at the Laboratory of Peptide Chemistry of the St. Petersburg Institute of Bioregulation and Gerontology.The geroprotective activity of Epitalon was studied in 3 strains of D. melanogaster. Epitalon increased the life-span of imagoes significantly by 11–16% when applied at unprecedentedly low concentrations-from 0.001*10-6 to 5*10-6 wt% of the culture medium. The effective concentrations of Epitalon were 16,000-80,000,000 times lower than those of melatonin. In another experiment, the mean life-span of female VES and male NA-flies increased under the influence of Epitalon by 26%. In NA- females the mean life-span grew by 35% and in NA- males, by 29%.
In our recent study the geroprotective effect of long-term Epitalon administration in female CBA mice was demonstrated.54 The number of mice that survived the age of 24 months increased 4 times under Epitalon influence as compared to the controls treated with saline. The bioregulator slowed down aging of the reproductive function, decreased physical activity, inhibited free radical processes, and decreased total spontaneous tumor incidence 1.7 times in female CBA mice.54 Epitalon inhibited mammary carcinogenesis and metastasis in HER-2/neu transgenic mice.55 The expression of HER-2/neu mRNA in the mammary tumors of HER-2/neu transgenic mice treated with Epitalon reduced 3.7-fold in comparison with the control animals. The administration of Epitalon inhibited colon and small intestine carcinogenesis induced by 1,2-dimethylhydrazine in rats.
Aging Interventions and Therapies || Pineal Peptides as Modulators of Aging Rattan, Suresh I S

Epitalon Preparation Products And Raw materials

Raw materials

Preparation Products

Epitalon Suppliers

Global( 221)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zhuzhou New Peptides Tech Co.,Ltd.	+8618073326374	sales@goodpeptides.com	China	140	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	999	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	+8618068519287	sales@xuanmingchem.com	China	823	58
Wuhan Nutra Biotechnology Co.,Ltd	+8617786394783	nutrabiotech@outlook.com	China	300	58
ZhenYiBio Technology Inc	+8615309206328	alexxue@zhenyibio.com	China	299	58
Sichuan Tai Hui Biotechnology Co., Ltd	+86-18224031330 +86-18081096520	404435307@qq.com	China	25	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
Shanghai Yunao International Trade Co., Ltd	+8617621705551	asdf@shanghaihg.cn	China	265	58
Shanghai Getian Industrial Co., LTD	+86-15373193816 +86-15373193816	mike@ge-tian.com	China	274	58
Shanghai Chinqesen Biotechnology Co., Ltd.	+86-16628886292 +86-19521323435	sales2@qschem-pharma.com	China	46	58

Supplier	Advantage
Zhuzhou New Peptides Tech Co.,Ltd.	58
Cellmano Biotech Limited	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	58
Wuhan Nutra Biotechnology Co.,Ltd	58
ZhenYiBio Technology Inc	58
Sichuan Tai Hui Biotechnology Co., Ltd	58
Nantong Guangyuan Chemicl Co,Ltd	58
Shanghai Yunao International Trade Co., Ltd	58
Shanghai Getian Industrial Co., LTD	58
Shanghai Chinqesen Biotechnology Co., Ltd.	58

View Lastest Price from Epitalon manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-05-21	Epitalon 307297-39-8	US $1.00-1.00 / g	1g	99%	100kg	Dorne Chemical Technology co. LTD
2024-05-21	Epithalon 307297-39-8	US $40.00-20.00 / box	1box	99.9%	500 box	hebei hongtan Biotechnology Co., Ltd
2024-05-21	Epithalon 307297-39-8	US $60.00-45.00 / box	1box	99.99%	1000	hebei hongtan Biotechnology Co., Ltd

Epitalon
307297-39-8
US $1.00-1.00 / g
99%
Dorne Chemical Technology co. LTD

Epithalon
307297-39-8
US $40.00-20.00 / box
99.9%
hebei hongtan Biotechnology Co., Ltd

Epithalon
307297-39-8
US $60.00-45.00 / box
99.99%
hebei hongtan Biotechnology Co., Ltd

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Epitalon L-alanyl-L-alpha-glutamyl-L-alpha-aspartylglycine 9: PN: WO02090380 PAGE: 55 claimed protein L-Alanyl-L-α-glutamyl-L-α-aspartylglycine Epithalon, Epithalon Tetra Peptide Epitalon, Epithalon TetraPeptide ALAGLUASPGLY Glycine, L-alanyl-L-α-glutamyl-L-α-aspartyl- Epitalon(Epithalon) Injectable Lyophillzed Powder Peptides Peptide Epitalon/Epithalon/Epithalone CAS 307297-39-8 10mg/Vial EPITHALON，EPITALON TETRAPEPTIDE Epithalon(Epitalon) acetate Epithalon(Epitalon) Epitaron Eptaton Epithalon Epithalon TetraPeptide Epithalon Epithalone (S)-4-((S)-2-Aminopropanamido)-5-(((S)-3-carboxy-1-((carboxymethyl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid EpithalonAcetate Glycine, L-alanyl-L-a-glutamyl-L-a-aspartyl- Epitalon 2mg/vial (4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid L-Alanyl-L-α-glutamyl-L-α-aspartylglycine O-AcetylEpitalonPeptide Pnc-27 Polypeptide Peptide N-Acetyl Epitalon /N-Acetyl Epitalon Amidate Epitalon high quirty Epithalamin epithalon 307297-39-8 30297-39-8 1307297-39-8 30729-39-8 307297-39-8