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N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine structure

CAS No.: 444731-74-2

Chemical Name:: N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine

Synonyms: BNKY007-PZ01;Pazopanib Impurity 20;2H-indazol-6aMine,2,3-diMethyl.HCl(1:1);N-(2-chloropyrimidin-4-yl)-2,3-dimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-;6-[N-(2-chloropyriMidin-4-yl)aMino]-2,3-diMethyl-2H-indazole;N-(2-chloropyrimidin-4-yl)-N,2,3-dimethyl-2H-indazol -6-amine;N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine ISO 9001：2015 REACH

CBNumber:: CB12526161

Molecular Formula:: C13H12ClN5

Molecular Weight:: 273.72

MDL Number:: MFCD17014818

MOL File:: 444731-74-2.mol

MSDS File:: SDS

Last updated:2024-04-01 10:36:07

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N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Properties

Melting point	>216oC (dec.)
Boiling point	550.0±35.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	Hygroscopic, Refrigerator, under inert atmosphere
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	2.56±0.30(Predicted)
color	Pale Orange to Light Brown
Stability	Hygroscopic

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C380080	N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine	444731-74-2	1g	$175	2021-12-16	Buy
Biosynth Carbosynth	FC32848	N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine	444731-74-2	250mg	$315	2021-12-16	Buy
Matrix Scientific	095743	N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine 95+%	444731-74-2	250mg	$439	2021-12-16	Buy
Biosynth Carbosynth	FC32848	N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine	444731-74-2	500mg	$525	2021-12-16	Buy
AK Scientific	X3179	N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine	444731-74-2	5g	$728	2021-12-16	Buy

Product number	Packaging	Price	Buy
C380080	1g	$175	Buy
FC32848	250mg	$315	Buy
095743	250mg	$439	Buy
FC32848	500mg	$525	Buy
X3179	5g	$728	Buy

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Chemical Properties,Uses,Production

Uses

N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine (N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine) is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Application

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine is a valuable organic compound that could be used to synthesize N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, N- (2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, and others.

Synthesis

2,3-dimethyl-6-amino-2H- indazole 5.00g,2,4-Dichloropyrimidine 13.9g and sodium bicarbonate 10.4g were dissolved in 100mL absolute ethanol and heated to 79°C.After refluxing for 4 h, cool to room temperature and filter. The cake was washed well with ethyl acetate, and the filtrate was collected. Concentrate under reduced pressure, remove the solvent, and fully beat with ethyl acetate and filter to give an off-white solid. Recrystallization from methanol gave 7.64 g of product N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine as a white solid, yield: 90.0%.

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine synthesis

Synthesis of N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine from 2,4-Dichloropyrimidine and 2,3-DIMETHYL-2H-INDAZOL-6-AMINE

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Preparation Products And Raw materials

Raw materials

2,3-DIMETHYL-2H-INDAZOL-6-AMINE 2,3-dimethyl-2H-indazol-6-amine hydrochloride 2,4-Dichloropyrimidine

Preparation Products

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Suppliers

Global( 133)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BIONNA MEDICINE CO.,LTD	01056380788-8515; +8618518759099	790226113@qq.com	China	52	58
Yangzhou Qinyuan Pharmatech Co.,ltd	+86-18752526868	jennysun@yzqyyykj.com	China	64	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15965	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9342	55
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	341	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58

Supplier	Advantage
BIONNA MEDICINE CO.,LTD	58
Yangzhou Qinyuan Pharmatech Co.,ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58

View Lastest Price from N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-06-22	N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine 444731-74-2	US $0.00 / g	10g	98%	10tons	Yangzhou Qinyuan Pharmatech Co.,ltd
2022-05-24	N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine 444731-74-2	US $1.10 / g	1g	99.0% Min	100 Tons	Dideu Industries Group Limited
2020-04-24	N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine 444731-74-2	US $0.10 / KG	1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd

N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine
444731-74-2
US $0.00 / g
98%
Yangzhou Qinyuan Pharmatech Co.,ltd

N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine
444731-74-2
US $1.10 / g
99.0% Min
Dideu Industries Group Limited

N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine
444731-74-2
US $0.10 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

444731-74-2(N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine)Related Search:

Pazopanib Related Compound 3 (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Pazopanib Impurity 9 N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

2,3-DIMETHYL-6-NITRO-2H-INDAZOLE Pazopanib Pazopanib-d6 2,3-dimethyl-2H-indazol-6-amine hydrochloride Pazopanib Related Compound 2

1,3-Dimethyl-6-nitro-1H-indazole 2-Methyl-5-nitrobenzenesulfonamide 3-AMINO-4-METHYLBENZENESULFONAMIDE 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI)

1,3-DiMethyl-6-aMino-1H-indazole 4(1H)-Pyrimidinone, 2-chloro- (9CI) Pazopanib Impurity 10

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N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine 2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl- N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-2H-indazol-6-aMine N-(2-chloropyrimidin-4-yl)-2,3-dimethylindazol-6-amine 2H-indazol-6aMine,2,3-diMethyl.HCl(1:1) 6-[N-(2-chloropyriMidin-4-yl)aMino]-2,3-diMethyl-2H-indazole Pazopanib Impurity 20 BNKY007-PZ01 N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine ISO 9001：2015 REACH N-(2-chloropyrimidin-4-yl)-N,2,3-dimethyl-2H-indazol -6-amine 444731-74-2