Nrf1-activator-1
- CAS No.
- 1474034-05-3
- Chemical Name:
- Nrf1-activator-1
- Synonyms
- CS-1306;RTA-408;Omaveloxolone;Nrf1-activator-1;RTA-408(Omaveloxolone);RTA-408;RTA 408;RTA408;Omaveloxolone (RTA-408);Clopidogrel Impurity 115;N-(2-Cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoropropanamide;Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-
- CBNumber:
- CB12705090
- Molecular Formula:
- C33H44F2N2O3
- Molecular Weight:
- 554.71
- MDL Number:
- MFCD28167769
- MOL File:
- 1474034-05-3.mol
| Boiling point | 662.0±55.0 °C(Predicted) |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥55.5 mg/mL in DMSO; insoluble in H2O; ≥25.05 mg/mL in EtOH |
| form | Powder |
| pka | 13.71±0.70(Predicted) |
| FDA UNII | G69Z98951Q |
| NCI Drug Dictionary | omaveloxolone |
Nrf1-activator-1 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17854 | RTA 408 ≥98% | 1474034-05-3 | 1mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 17854 | RTA 408 ≥98% | 1474034-05-3 | 5mg | $250 | 2024-03-01 | Buy |
| Cayman Chemical | 17854 | RTA 408 ≥98% | 1474034-05-3 | 10mg | $468 | 2024-03-01 | Buy |
| Cayman Chemical | 17854 | RTA 408 ≥98% | 1474034-05-3 | 25mg | $1019 | 2024-03-01 | Buy |
| TRC | R700990 | RTA408 | 1474034-05-3 | 25mg | $1155 | 2021-12-16 | Buy |
Nrf1-activator-1 Chemical Properties,Uses,Production
Uses
Synthetic triterpenoids, such as RTA 408, are antioxidant inflammation modulator (AIM) that can inhibit tumor cell growth and metastasis via oncogenic signaling pathways. RTA 408 is an anticancer, anti-inflammatory, and antioxidant agent that protects human retinal pigment epithelial cells against H2O2-induced cell injury by activating NF-E2-related factor 2.
Biological Activity
omaveloxolone (rta-408) is a novel synthetic triterpenoid that binds to kelch-like ech-associated protein 1 (keap1) and attenuate nuclear factor erythroid 2-related factor 2 (nrf2) degradation [1].keap1 is involved in proteasomal degradation of nrf2, thereby maintaining low basal levels of nrf2. binding to keap1 and blocking its ability to promote nrf2 degradation increase newly synthesized nrf2 accumulated in the nucleus where nrf2 increases the expression of antioxidant genes and decreases the expression of pro-inflammatory genes [1].in interferon-γ-stimulated raw 264.7 macrophage cells, low concentrations (≤ 25 nm) of rta-408 activated nrf2 and lowered nitric oxide and pro-inflammatory cytokine levels. at higher concentrations, rta-408 inhibited tumor cell growth, with gi50 of 260 ± 74 nm. meanwhile, rta-408 increased caspase activity in tumor cell lines, but not in normal primary human cells.in mice with radiation-induced dermatitis, topical application of rta-408 (0.01%, 0.1% and 1.0%, q.d.) resulted in dose-dependent improvements in the appearance of skin, with 1.0% rta-408 markedly reducing epidermal and collagen thickening, preventing dermal necrosis, and completely alleviating skin ulcers [2].[1]. probst b l, trevino i, mccauley l, et al. rta 408, a novel synthetic triterpenoid with broad anticancer and anti-inflammatory activity. plos one, 2015, 10(4): e0122942.[2]. reisman s a, lee c y, meyer c j, et al. topical application of the synthetic triterpenoid rta 408 protects mice from radiation-induced dermatitis. radiation research, 2014, 181(5): 512-520.
Nrf1-activator-1 Preparation Products And Raw materials
Raw materials
Preparation Products
Nrf1-activator-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
